One-step conjugation of glycylglycine with [F-18]FDG and a pilot PET imaging study

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dc.contributor.authorSenisik, A. M.
dc.contributor.authorIchedef, C.
dc.contributor.authorKilcar, A. Y.
dc.contributor.authorUcar, E.
dc.contributor.authorAri, K.
dc.contributor.authorGoksoy, D.
dc.contributor.authorParlak, Y.
dc.contributor.authorBilgin, Bedriye Elvan Sayit
dc.contributor.authorTeksoz, S.
dc.date.accessioned2019-10-27T10:06:18Z
dc.date.available2019-10-27T10:06:18Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractThis study describes a single step conjugation of Glycylglycine (GlyGly) which is a small peptide, with [F-18]FDG via oxime formation. Amiooxy-functionalization of GlyGly (AO-GlyGly) was accomplished through the reaction of Boc-aminooxy succinimide ester. Conjugation reaction was performed at 100 A degrees C for 30 min in a vial containing AO-GlyGly and [F-18]FDG solution. The radiolabeled product ([F-18]FDG-GlyGly) was obtained with 98.65 +/- 0.35% yield without any purification step which makes this method more attractive for F-18 radiolabeling. The present study is concluded with an in vivo pilot animal PET study to assess biodistribution and kinetics of chemoselectively [F-18]FDG tagged GlyGly in vivo.en_US
dc.description.sponsorshipEge University Scientific Research Project (Bomova, Izmir, Turkey)Ege University [2012 NBE 004]en_US
dc.description.sponsorshipThis study was financially supported by the Ege University Scientific Research Project numbered 2012 NBE 004 (Bomova, Izmir, Turkey).en_US
dc.identifier.doi10.1007/s10967-018-5772-x
dc.identifier.endpage463en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issn0236-5731en_US
dc.identifier.issn1588-2780en_US
dc.identifier.issue2en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-018-5772-x
dc.identifier.urihttps://hdl.handle.net/11454/30441
dc.identifier.volume316en_US
dc.identifier.wosWOS:000431040600006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFDGen_US
dc.subjectImagingen_US
dc.subjectGlycylglycineen_US
dc.subjectPETen_US
dc.subjectRadiopharmaceuticalsen_US
dc.titleOne-step conjugation of glycylglycine with [F-18]FDG and a pilot PET imaging studyen_US
dc.typeArticleen_US

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