The Effect of Hyperbaric Oxygen Therapy on Fos Expression in Rat Spinal Cord Neurons Following Spinal Cord Injury

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dc.contributor.authorKeser, Aysegul
dc.contributor.authorErturk, Mete
dc.contributor.authorDagci, Taner
dc.contributor.authorAydin, Figen
dc.contributor.authorSengul, Gulgun
dc.date.accessioned2019-10-27T22:29:02Z
dc.date.available2019-10-27T22:29:02Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: We investigated the effect of hyperbaric oxygen (HBO) therapy on Fos protein expression in spinal cord neurons in rats following spinal cord injury (SCI). Methods: Rivlin and Tator clip method was used to produce SCI at T9-T11 in Sprague-Dawley rats (n=16) divided into four groups. 1. Control (SCI, no HBO), 2. Preoperative HBO (HBO five days before SCI), 3. Postoperative HBO (HBO just after SCI for five days), 4. Pre- and postoperative HBO (HBO five days before SCI and after SCI for five days). Rats received HBO at 2.80 ATA 60 min daily. Results: Fos immunohistochemistry was used to localize neurons following SCI and HBO therapy in spinal cord segments 1 cm proximal and 1 cm distal to SCI. HBO applied preoperatively, postoperatively and pre- and postoperatively significantly increased Fos expression in the spinal cord. The increase corresponded with the duration of HBO therapy. In all groups, Fos expression was mostly in laminae 1-2, followed by 3-4, and 7-8. This is the first study showing the effect of HBO therapy on Fos expression in rats with SCI. Conclusion: Nitric oxide is involved in nociception. In this study, we expected a decrease in Fos following HBO therapy in SCI accordingly; however, this was not the case, suggesting the increase in Fos is not related to pain, but possibly to mechanisms related to neuroprotection.en_US
dc.description.sponsorshipEge University, School of Medicine Research FundEge University [BAP 2011TIP30]en_US
dc.description.sponsorshipThis study was supported by Ege University, School of Medicine Research Fund (BAP 2011TIP30).en_US
dc.identifier.endpage689en_US
dc.identifier.issn1302-1664
dc.identifier.issn1302-1664en_US
dc.identifier.issue4en_US
dc.identifier.startpage680en_US
dc.identifier.urihttps://hdl.handle.net/11454/51030
dc.identifier.volume32en_US
dc.identifier.wosWOS:000368518700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal of Neurological Sciences-Turkishen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFosen_US
dc.subjectHyperbaric oxygenen_US
dc.subjectRaten_US
dc.subjectSpinal cord injuryen_US
dc.titleThe Effect of Hyperbaric Oxygen Therapy on Fos Expression in Rat Spinal Cord Neurons Following Spinal Cord Injuryen_US
dc.typeArticleen_US

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