Radiolabeling of codeine with I-131 and its biodistribution in rats

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dc.contributor.authorEnginar, H.
dc.contributor.authorUnak, P.
dc.contributor.authorLambrecht, F. Y.
dc.contributor.authorMuftuler, F. Z. Biber
dc.contributor.authorMedine, E. I.
dc.contributor.authorYolcular, S.
dc.contributor.authorYurt, A.
dc.contributor.authorSeyitoglu, B.
dc.contributor.authorBulduk, I.
dc.date.accessioned2019-10-27T20:52:12Z
dc.date.available2019-10-27T20:52:12Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description2nd International Nuclear Chemistry Congress (2nd-INCC) -- APR 13-17, 2008 -- Cancun, MEXICOen_US
dc.description.abstractCodeine which was extracted from dry capsules of the opium poppy (Papaver somniferum) was purified by HPLC (High Performance Liquid Chromatography) and characterized by NMR (Nuclear Magnetic Resonance) and IR (Infrared) spectroscopy techniques. The purified compound was labeled with I-131 and biodistribution studies were performed in rats. Radioiodinated codeine distributed uniformly in the cerebellum, m.pons, striatum and hypothalamus while the other branch of brain and Stomach, urinary bladder, and small intestine uptakes were significantly higher than other tissues.en_US
dc.identifier.doi10.1007/s10967-009-0528-2
dc.identifier.endpage370en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issn0236-5731en_US
dc.identifier.issn1588-2780en_US
dc.identifier.issue2en_US
dc.identifier.startpage363en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-009-0528-2
dc.identifier.urihttps://hdl.handle.net/11454/43203
dc.identifier.volume280en_US
dc.identifier.wosWOS:000265714000028en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleRadiolabeling of codeine with I-131 and its biodistribution in ratsen_US
dc.typeArticleen_US

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