Cut-Off Values of Specific IgE and Skin Prick Test to Predict Oral Food Challenge Positivity in Children with Cow’s Milk Allergy

Basit Öğe Kaydı
dc.authorscopusid37092966400
dc.authorscopusid56331939200
dc.authorscopusid9036191300
dc.authorscopusid57211857542
dc.authorscopusid6602303657
dc.authorscopusid56946643200
dc.authorscopusid7004473191
dc.contributor.authorGünaydın N.C.
dc.contributor.authorAkarcan S.E.
dc.contributor.authorGülen F.
dc.contributor.authorBal C.M.
dc.contributor.authorTanaç R.
dc.contributor.authorAtasever M.
dc.contributor.authorDemir E.
dc.date.accessioned2023-01-12T20:26:30Z
dc.date.available2023-01-12T20:26:30Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractObjective: The cut-off values for the skin prick test diameters and cow’s milk-specific IgE mea-surements are used to predict the result of the oral food challenge test for the diagnosis of cow’s milk allergy. This study aimed to determine the diagnostic values of skin prick test and cow’s milk-specific IgE according to age groups and compare the diagnostic powers of these 2 methods. Materials and Methods: In total, 153 children who had a preliminary diagnosis of cow’s milk allergy were evaluated. Group A (n = 90) consisted of cow’s milk allergy patients whose diagnosis was confirmed by a positive oral food challenge or a history of anaphylaxis. Group B (n = 63) was composed of patients with a negative oral food challenge. The demographic, clinical, and laboratory findings of 2 groups were compared. Results: The cut-off points for cow’s milk-specific IgE and cow’s milk-skin prick test were determined as >2.12 kUA/L and >5 mm, respectively. The area under the curve was 0.844 for cow’s milk-skin prick test (sensitivity 73%, specificity 84%) and 0.745 for cow’s milk-specific IgE (sensitivity 67%, specificity 86%). The diagnostic power of skin prick test was determined to be higher when compared to cow’s milk-specific IgE (P = .02). According to the predicted probability curves, decision points for cow’s milk-specific IgE and cow’s milk-skin prick test with 95% probability were determined as follows, respectively: for ?24 months: 22 kUA/L, 11.3 mm; for >24 months: 44.1 kUA/, 15.1 mm. The lowest cut-off value with a positive predictive value of 95% and a specificity of 96% was found in patients <1-year-old (>3.3 kUA/L) Conclusion: The use of high probability diagnostic values of communities for specific IgE anskin prick test along with a significant clinical history may provide accurate and rapid diagnosof cow’s milk allergy and facilitate patient follow-up. © 2022, AVES. All rights reserved.en_US
dc.description.sponsorshipFunding: The authors declared that this study received no financial support.en_US
dc.identifier.doi10.5152/TurkArchPediatr.2022.22134
dc.identifier.endpage610en_US
dc.identifier.issn27576256
dc.identifier.issn2757-6256en_US
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85140320060en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage603en_US
dc.identifier.urihttps://doi.org/10.5152/TurkArchPediatr.2022.22134
dc.identifier.urihttps://hdl.handle.net/11454/80030
dc.identifier.volume57en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAVESen_US
dc.relation.ispartofTurkish Archives of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildrenen_US
dc.subjectcow's milk allergyen_US
dc.subjectdecision pointen_US
dc.subjectskin prick testen_US
dc.subjectspecific IgEen_US
dc.subjectimmunoglobulin Een_US
dc.subjectallergic rhinitisen_US
dc.subjectanaphylaxisen_US
dc.subjectangioneurotic edemaen_US
dc.subjectarea under the curveen_US
dc.subjectArticleen_US
dc.subjectasthmaen_US
dc.subjectatopic dermatitisen_US
dc.subjectchilden_US
dc.subjectcontrolled studyen_US
dc.subjectcow milken_US
dc.subjectdemographyen_US
dc.subjectdiagnostic valueen_US
dc.subjectenzyme immunoassayen_US
dc.subjectfemaleen_US
dc.subjectfollow upen_US
dc.subjectfooden_US
dc.subjecthumanen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmilk allergyen_US
dc.subjectpredictive valueen_US
dc.subjectpreschool childen_US
dc.subjectprick testen_US
dc.subjectprobabilityen_US
dc.subjectreceiver operating characteristicen_US
dc.subjectrespiratory distressen_US
dc.subjectretrospective studyen_US
dc.subjectsensitivity and specificityen_US
dc.subjecturticariaen_US
dc.titleCut-Off Values of Specific IgE and Skin Prick Test to Predict Oral Food Challenge Positivity in Children with Cow’s Milk Allergyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu