Periorbital sebaceous carcinoma with intracranial extension: A case report

Sebaceous carcinoma, typically originating from the meibomian glands of the eyelids, is a rare malignant tumor with a propensity for diffuse, invasive growth. Intracranial extension of this carcinoma is exceptionally rare, with only a few cases reported. Here, we present an uncommon case of sebaceous carcinoma with extension to the cavernous sinus, Meckel's cave, and the temporal lobe. The patient underwent surgery and radiotherapy, resulting in regression of the tumor. However, a secondary meningioma associated with prior radiotherapy was identified on follow-up imaging. Regular monitoring is crucial for early detection of recurrent or metastatic disease. The necessity of optimal patient care through multidisciplinary collaboration in managing complex cases is highlighted in this report. Close follow-up and individualized treatment planning are essential for ensuring the best outcomes in such cases. © 2025, Ondokuz Mayis Universitesi. All rights reserved.