Behaviour of 9-Ethyl-9H-carbazole hydrazone derivatives against oxidant systems: Protective effect on amyloid ß-induced damage

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dc.contributor.authorKaraaslan C.
dc.contributor.authorInce E.
dc.contributor.authorGurer-Orhan H.
dc.contributor.authorTavakkoli M.
dc.contributor.authorFiruzi O.
dc.contributor.authorSaso L.
dc.contributor.authorSuzen S.
dc.date.accessioned2019-10-27T08:01:30Z
dc.date.available2019-10-27T08:01:30Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractAntioxidants are helpful in prevention of several diseases related with oxidative stress including neurodegenerative disorders. In recent studies, carbazoles were given proof of promising antioxidant activities. In this article, 9-ethyl-9H-carbazole hydrazone derivatives were synthesized, characterized and their invitroantioxidant activity and possible cytotoxic effects were investigated. Furthermore, protective effect of the synthesized derivatives against amyloid ß-induced damage in PC12 neuronal cells was examined by using MTT assay. The newly synthesized carbazoles were found to have radical scavenging activity with a varying potency both in cell-free and cell-basedinvitroassays. Several compounds, especially such as 3d and 3e, 3m and 3n bearing two halogen groups on the phenyl ring, were found to have cytotoxic activity. However, their cytotoxic activities were not higher than that of melatonin. Several compounds also significantly protected neuronal PC12 cells against amyloid ß-induced damage, which can be defined as neuroprotective agents. (4-(2-((9-Ethyl-9H-carbazol-3-yl)methylene)-hydrazinyl)benzonitrile) 3r was found as the most active compound with both radical scavenging activity and neuroprotective effects against amyloid ß-induced damage. These findings might provide an alternative strategy for developing novel carbazole derivatives for management of neurodegenerative diseases, such as Alzheimer's disease. © 2019 Croatian Chemical Society. All rights reserved.en_US
dc.identifier.doi10.5562/cca3481
dc.identifier.issn0011-1643
dc.identifier.issn0011-1643en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.5562/cca3481
dc.identifier.urihttps://hdl.handle.net/11454/25006
dc.identifier.volume92en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCroatian Chemical Societyen_US
dc.relation.ispartofCroatica Chemica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectAntioxidanten_US
dc.subjectCarbazoleen_US
dc.subjectCytotoxicityen_US
dc.subjectß-amyloiden_US
dc.titleBehaviour of 9-Ethyl-9H-carbazole hydrazone derivatives against oxidant systems: Protective effect on amyloid ß-induced damageen_US
dc.typeArticleen_US

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