Value of cervicovaginal prolactin in the prediction of spontaneous preterm delivery

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dc.contributor.authorKoca, ZD
dc.contributor.authorOztekin, MK
dc.contributor.authorKaradadas, N
dc.contributor.authorOzsener, S
dc.contributor.authorAsena, U
dc.date.accessioned2019-10-27T11:50:51Z
dc.date.available2019-10-27T11:50:51Z
dc.date.issued1999
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective Our purpose was to determine whether decidual prolactin could be identified in cervicovaginal secretions during pregnancy and whether its occurrence was associated with preterm delivery. Methods A prospective cohort: study was performed in 75 pregnant women. The study group comprised 35 patients hospitalized with the diagnosis of preterm labor or threatened preterm labor (11 and 24 patients, respectively) and the control group consisted of 40 asymptomatic outpatients. The cervicovaginal samples were collected with cervicovaginal washing and were then centrifuged. The supernatant was stored at -50 degrees C and the cervicovaginal prolactin levels were determined by radioimmunoassay. A prolactin concentration greater than the cut-off value calculated from the control group was considered positive. Results The median prolactin values in the 11 patients diagnosed with preterm labor were higher than in the control group (p < 0.05). The proportion of inpatients delivered at < 37 weeks' gestation was significantly greater in the group with positive prolactin values than in those testing negative in both the study and the control groups (p<0.01). The cervicovaginal prolactin assessment had an 82.3% positive predictive value and a 66.6% negative predictive value for delivery at <37 weeks' gestation in the symptomatic patients. Conclusions Cervicovaginal prolactin assessment as a biochemical marker may be used for the prediction of preterm delivery. It may also be used as a screening method for asymptomatic gravidas. Although there are not enough conclusive studies proving the use of cervicovaginal prolactin as a practical clinical assessment tool, there should be further studies of the biochemical markers of the decidual membranes, and of the cytotrophoblasts.en_US
dc.identifier.endpage125en_US
dc.identifier.issn1359-8635
dc.identifier.issn1359-8635en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage120en_US
dc.identifier.urihttps://hdl.handle.net/11454/34405
dc.identifier.volume4en_US
dc.identifier.wosWOS:000081237800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherParthenon Publishing Groupen_US
dc.relation.ispartofPrenatal and Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpreterm laboren_US
dc.subjectpreterm deliveryen_US
dc.subjectcervicovaginal prolactinen_US
dc.titleValue of cervicovaginal prolactin in the prediction of spontaneous preterm deliveryen_US
dc.typeArticleen_US

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