Correlation of ADC values measured using 3T diffusion-weighted MRI and SUVs from fluorodeoxyglucose PET/CT in head and neck squamous cell carcinomas

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dc.contributor.authorÇolak, E.
dc.contributor.authorBayraktaroğlu, S.
dc.contributor.authorAkagündüz, O.
dc.contributor.authorSavaş, R.
dc.contributor.authorEsassolak, M.
dc.date.accessioned2020-12-01T11:52:54Z
dc.date.available2020-12-01T11:52:54Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractAims: The aim of our study was to assess the correlations between apparent diffusion coefficient (ADC) values and standardized uptake values (SUVs) and their correlations with tumor size, tumor stage and histological grade in patients with head and neck squamous cell carcinomas (HNSSCs). Methods: This retrospective study included 36 patients with histologically confirmed HNSSCs visible on diffusion weighted imaging (DWI) and fluorodeoxyglucose (FDG) positron emission tomography (PET/CT). Correlations of minimum ADC (ADCmin), mean ADC (ADCmean), and minimum-mean ADC ratio (ADCmin/mean) with maximum SUV (SUVmax) and lean body mass SUVlbm (SUVlbm) were analyzed using the Spearman's correlation test. The Kruskal-Wallis one-way ANOVA test and Mann-Whitney U test were used to assess the correlations of ADC values and SUVs with tumor size, tumor stage and histological grade. Two experienced readers measured the ADC and SUVs independently, and intraclass correlation coefficient (ICC) was used to analyze the inter-observer agreement. Results: The mean ADCmin, ADCmean, and ADCmin/mean for HNSSCs were 0.68±0.17x10-3 mm2/s, 0.82±0.17x10-3 mm2/s, and 0.83±0.10, respectively. The mean SUVmax and SUVlbm were 14.65±5.5 and 10.96±5.1, respectively. The correlations between ADC values and SUVs did not reach statistical significance. There were no significant correlations of ADC values and SUVs with tumor size, tumor stage or histological grade. There was a tendency of SUVs to increase and ADC values to decrease with tumor dedifferentiation; however, the changes were not significant. Inter-observer agreement for tumor ADC values and SUVs was almost perfect (ICC>0.81). Conclusions: Pretreatment ADC values and SUVs in HNSSCs are reproducible and independent biomarkers. © 2020 Galenos Publishing House.en_US
dc.description.sponsorshipreceived no financial support.en_US
dc.identifier.doi10.4274/GULHANE.GALENOS.2019.735
dc.identifier.endpage79en_US
dc.identifier.issn1302-0471
dc.identifier.issn1302-0471en_US
dc.identifier.scopus2-s2.0-85087160921en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage72en_US
dc.identifier.urihttps://doi.org/10.4274/GULHANE.GALENOS.2019.735
dc.identifier.urihttps://hdl.handle.net/11454/61680
dc.identifier.volume62en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGalenos Publishing Houseen_US
dc.relation.ispartofGulhane Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApparent diffusion coefficienten_US
dc.subjectDiffusion-weighted magnetic resonance imagingen_US
dc.subjectHead and neck squamous cell carcinomaen_US
dc.subjectPositron emission tomographyen_US
dc.subjectStandardized uptake valueen_US
dc.titleCorrelation of ADC values measured using 3T diffusion-weighted MRI and SUVs from fluorodeoxyglucose PET/CT in head and neck squamous cell carcinomasen_US
dc.typeArticleen_US

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