Niosomes of Nerium oleander extracts: In vitro assessment of bioactive nanovesicular structures

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dc.contributor.authorGunes, Aybike
dc.contributor.authorGuler, Emine
dc.contributor.authorUn, Rabia Nur
dc.contributor.authorDemir, Bilal
dc.contributor.authorBarlas, E. Baris
dc.contributor.authorYavuz, Murat
dc.contributor.authorCoskunol, Hakan
dc.contributor.authorTimur, Suna
dc.date.accessioned2019-10-27T11:10:55Z
dc.date.available2019-10-27T11:10:55Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractNiosomes are known as non-ionic surfactant-based vesicles and have been used quite a lot for medical applications as a novel drug delivery system in recent years. Herein we describe, the preparation and characterization of niosomes containing oleander (Nerium oleander) (ONs) extract as the herbal compound. In this context, niosomal formulations of two different extracts obtained from oleander roots were prepared by a thin film hydration technique using Tween 60 (non-ionic surfactant) with a cholesterol mixture at 1:1 M ratio. These vesicular structures were characterised by various techniques such as atomic force microscopy, zeta potential and dynamic light scattering size measurements. ONs vesicles are less than 100 nm in size with a good physical stability more than 50 days. Initially, total phenolic and flavonoid contents and antioxidant activities of the extracts were investigated. The methanol extract of oleander roots (MOE) showed higher polyphenolic content and exhibits a better antioxidant activity in compared to the hydro-methanol (20% methanol) extract (MOWE). Total phenolic contents in the MOE and MOWE were calculated as 64.51 +/- 0.945 mu g/mg and 65.05 +/- 0.37 mu g/mg gallic acid equivalents, respectively. Encapsulation efficiencies of the vesicles were found as 16.2% for MON (contain MOE) and 13.24% for MWON (contain MOWE). The significant linear correlation Was confirmed between the antioxidant activity and total phenolic content of extracts as well as ONs. Cell based cytotoxic activities of methanol extract and MON formulations were also assessed via KIT assay using Hela and A549 cell lines. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [2209/A]en_US
dc.description.sponsorshipThe project outlined in this paper was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) 2209/A Research Projects Support Program for University Students.en_US
dc.identifier.doi10.1016/j.jddst.2016.12.013
dc.identifier.endpage165en_US
dc.identifier.issn1773-2247
dc.identifier.issn1773-2247en_US
dc.identifier.startpage158en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2016.12.013
dc.identifier.urihttps://hdl.handle.net/11454/32445
dc.identifier.volume37en_US
dc.identifier.wosWOS:000393626900019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBioactive materialsen_US
dc.subjectDrug carrieren_US
dc.subjectNerium oleanderen_US
dc.subjectNiosomeen_US
dc.subjectAntioxidant activityen_US
dc.subjectCytotoxicityen_US
dc.titleNiosomes of Nerium oleander extracts: In vitro assessment of bioactive nanovesicular structuresen_US
dc.typeArticleen_US

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