Deacetylation of Histones and Non-histone Proteins in Inflammatory Diseases and Cancer Therapeutic Potential of Histone Deacetylase Inhibitors

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dc.authorscopusid57213828166
dc.authorscopusid8558322700
dc.contributor.authorMan, Ezgi
dc.contributor.authorEvran, Serap
dc.date.accessioned2024-08-25T18:45:55Z
dc.date.available2024-08-25T18:45:55Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractEpigenetic changes play an important role in the pathophysiology of autoimmune diseases such as allergic asthma, multiple sclerosis, lung diseases, diabetes, cystic fibrosis, atherosclerosis, rheumatoid arthritis, and COVID-19. There are three main classes of epigenetic alterations: post-translational modifications of histone proteins, control by non-coding RNA and DNA methylation. Since histone modifications can directly affect chromatin structure and accessibility, they can regulate gene expression levels. Abnormal expression and activity of histone deacetylases (HDACs) have been reported in immune mediated diseases. Increased acetylated levels of lysine residues have been suggested to be related to the overexpression of inflammatory genes. This review focuses on the effect of HDAC modifications on histone and non-histone proteins in autoimmune diseases. Furthermore, we discuss the potential therapeutic effect of HDAC inhibitors (HDACi) used in these diseases.en_US
dc.identifier.doi10.2174/0113892029265046231011100327
dc.identifier.endpage145en_US
dc.identifier.issn1389-2029
dc.identifier.issn1875-5488
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85178132110en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage136en_US
dc.identifier.urihttps://doi.org/10.2174/0113892029265046231011100327
dc.identifier.urihttps://hdl.handle.net/11454/101733
dc.identifier.volume24en_US
dc.identifier.wosWOS:001126428100002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofCurrent Genomicsen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectAutoimmune diseasesen_US
dc.subjectepigeneticsen_US
dc.subjecthistone protein modificationsen_US
dc.subjectnon-histone protein modificationsen_US
dc.subjectHDACsen_US
dc.subjectHDAC inhibitorsen_US
dc.subjectlysine deacetylationen_US
dc.subjecthistone deacetylaseen_US
dc.subjectHdac Inhibitorsen_US
dc.subjectExpressionen_US
dc.subjectArthritisen_US
dc.subjectCellsen_US
dc.titleDeacetylation of Histones and Non-histone Proteins in Inflammatory Diseases and Cancer Therapeutic Potential of Histone Deacetylase Inhibitorsen_US
dc.typeReview Articleen_US

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