Does omeprazole effect leukocyte function? [OMEPRAZOL NOTROFIL LOKOSIT FONKSIYONLARINI ETKILER MI?]

In this study, in vitro adhesion and chemotaxis of leukocytes have been searched in rabbits. Animals were divided into three groups as control, sepsis and sepsis plus omeprazol. Inhibited in the last group differences between adhesion percentages were nonsignificant. As a result H/K ATPase enzyme system has not only been seen in gastric parietal cells, but also in neutrophils, and omeprazol might effect neutrophil leucocyte functions. That observation needs to be supported by randomized and double blind clinical trials.