The relationship between cagA positivity and serum gastrin and TNF- alpha levels in patients with chronic active gastritis and duodenal ulcer associated with Helicobacter pylori [Helicobacter pylori (+) kronik aktif gastrit ve duodenal ulserli hastalarda, cagA pozitifligi ile serum gastrin ve TNF-alfa iliskisi]

Basit Öğe Kaydı
dc.contributor.authorYilmaz M.
dc.contributor.authorAydin A.
dc.contributor.authorUngan M.
dc.contributor.authorGunsar F.
dc.contributor.authorErsoz G.
dc.contributor.authorOzutemiz O.
dc.contributor.authorAkarca U.
dc.contributor.authorCavusoglu H.
dc.date.accessioned2019-10-27T00:26:48Z
dc.date.available2019-10-27T00:26:48Z
dc.date.issued1999
dc.departmentEge Üniversitesien_US
dc.description.abstractHelicobacter pylori (H.pylori) infection, which is strongly associated with non-autoimmune chronic active gastritis and peptic ulcer disease, is also considered to be a co-factor in gastric adenocarcinoma and primer gastric B cell lymphoma. In order to examine the relationship between cag A (+) strain of H. pylori with gastrin and TNF-alpha, an inflammatory mediator, in both chronic active gastritis (CAG) and duodenal ulcer (DU) pathogenesis, 21 patients with CAG and 31 patients with DU disease were investigated in addition to 18 patients who had no pathological findings on either upper gastrointestinal endoscopy or histological examination. Prior to endoscopy, sera were collected from all of cases in order to evaluate gastrin and TNF- alpha and also for cag A antibody measurements. These three parameters were studied from the same blood sample. Cag A antibody was found in 33.3% (7/21) of patients with CAG and in 64.5% (20/31) of patients with DU disease (p < 0.05). When the cases with CAG (74.1 ± 26 pg/ml) and with DU (69.5 ± 22 pg/ml) were compared there was no significant difference between gastrin levels of the patient groups but both were significantly higher than the gastrin level (44.9 ± 5.7 pg/ml) of the control group (p < 0.001). The serum TNF-alpha level of cases with CAG (38 ± 34 pg/ml) was higher than control group (18 ± 9 pg/ml) (p < 0.05). There was no significant/difference between the serum gastrin and TNF-alpha levels of cag A(+) and cagA(-) cases. According to these results, there seems to be a positive relationship between cag A positive H. pylori strains and DU. Serum gastrin levels are high in H. pylori infection. This finding does not depend on the presence of cagA antibody of H. pylori and is also not related with CAG and DU, which are caused by H. pylori. As there is no correlation between the serum TNF-alpha level, gastrin level and presence of cagA antibody, we conclude that both the secretion of gastrin and the inflammatory cytokin response are free from the effect of cag A antibody.en_US
dc.identifier.endpage390en_US
dc.identifier.issn1300-4948
dc.identifier.issn1300-4948en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage385en_US
dc.identifier.urihttps://hdl.handle.net/11454/23443
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCag Aen_US
dc.subjectGastrinen_US
dc.subjectGastritisen_US
dc.subjectHelicobacter pylorien_US
dc.subjectPeptic ulceren_US
dc.subjectTNF-alphaen_US
dc.titleThe relationship between cagA positivity and serum gastrin and TNF- alpha levels in patients with chronic active gastritis and duodenal ulcer associated with Helicobacter pylori [Helicobacter pylori (+) kronik aktif gastrit ve duodenal ulserli hastalarda, cagA pozitifligi ile serum gastrin ve TNF-alfa iliskisi]en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu