The role of microsatellite instability to predict clinical benefit from irinotecan-based regimens in metastatic colorectal cancer

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dc.contributor.authorArtaç M.
dc.contributor.authorPehlivan S.
dc.contributor.authorAkcan S.
dc.contributor.authorPehlivan M.
dc.contributor.authorGelen T.
dc.contributor.authorItirli G.
dc.contributor.authorAksoy N.
dc.contributor.authorÖzdogan M.
dc.contributor.authorSavaş B.
dc.contributor.authorSamur M.
dc.contributor.authorBozcuk H.
dc.date.accessioned2019-10-26T23:58:07Z
dc.date.available2019-10-26T23:58:07Z
dc.date.issued2008
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of our study was to assess the relationship between microsatellite instability (MSI) and the clinical outcome in metastatic colorectal cancer (CRC) patients treated with irinotecan-based regimens. We assessed best objective response, progression free survival (PFS) and overall survival (OAS) in relation to MSI analysis that was performed using BAT-25, BAT-26, D5S346, D2S123, D17S250 markers in normal and tumor DNA. The best objective response was significantly and negatively related with the D17S250 (an adjacent locus to p53) microsatellite marker (p=0.047). However, MSI score was not related with the best objective response (p=0.88). There was again no relationship between PFS, OAS and MSI score. In conclusion, this study allowed us to establish in a prospective study design that MSI status did not predict survival in metastatic colorectal cancer patients treated with irinotecan-based regimens.en_US
dc.identifier.endpage56en_US
dc.identifier.issn1019-3103
dc.identifier.issn1019-3103en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://hdl.handle.net/11454/21152
dc.identifier.volume38en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColon canceren_US
dc.subjectIrinotecanen_US
dc.subjectMicrosatellite instabilityen_US
dc.subjectPCRen_US
dc.titleThe role of microsatellite instability to predict clinical benefit from irinotecan-based regimens in metastatic colorectal canceren_US
dc.typeArticleen_US

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