Cytotoxic potential of Wagner's Viper, Montivipera wagneri, venom

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dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorIgci, Nasit
dc.contributor.authorGocmen, Bayram
dc.contributor.authorMebert, Konrad
dc.date.accessioned2019-10-27T11:23:51Z
dc.date.available2019-10-27T11:23:51Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractSnake venoms contain a variety of biologically active proteins, which have therapeutic potential. Montivipera wagneri is an endemic mountain viper species of Turkey. In this study, the cytotoxic activity of M. wagneri crude venom was investigated against A549, HeLa, CaCo-2, U-87MG, PC3 and MCF-7 cancerous cells and non-cancerous cells Vero and HEK293 by MTT assay. The IC50 values of M. wagneri crude venom on cultured cells varied from 1.02 +/- 0.02 to 19.76 +/- 0.42 mu g/ml, with the most potent activities against A549 and CaCo-2 cells. The present work documents the venom of M. wagneri for the first time, showing promising results as a potential source for cytotoxic proteins or peptides.en_US
dc.identifier.endpage291en_US
dc.identifier.issn1584-9074
dc.identifier.issn1842-6441
dc.identifier.issn1584-9074en_US
dc.identifier.issn1842-6441en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage286en_US
dc.identifier.urihttps://hdl.handle.net/11454/33216
dc.identifier.volume12en_US
dc.identifier.wosWOS:000390429300009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Oradea Publ Houseen_US
dc.relation.ispartofNorth-Western Journal of Zoologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsnake venomen_US
dc.subjectMontivipera wagnerien_US
dc.subjectcytotoxicityen_US
dc.titleCytotoxic potential of Wagner's Viper, Montivipera wagneri, venomen_US
dc.typeArticleen_US

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