A Study on Prophylactic Efficacies of Daptomycin and Vancomycin in a Rat Model of MRSA Infection Secondary to Spinal Implantation

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dc.contributor.authorOzer, Oner
dc.contributor.authorOzer, Fusun D.
dc.contributor.authorAkcay, Emrah
dc.contributor.authorAtci, Ibrahim Burak
dc.contributor.authorKocaman, Umit
dc.contributor.authorOzinel, Mehmet Ali
dc.contributor.authorVardar, Ender
dc.contributor.authorOzdemir, Nail
dc.date.accessioned2019-10-27T21:53:34Z
dc.date.available2019-10-27T21:53:34Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractThe present study aims to investigate the prophylactic effects of daptomycin and vancomycin in an experimental spinal infection induced by spinal implantation. The study involved inoculation of a bacterial suspension prepared with the MRSA ATCC 43300 strain to the implant bed and to the peripheral tissue immediately the implantation of titanium spinal implants to the bone in adult Winstar rats. The animals were divided into three groups; seven rats in the first group received no antibiotics, while the seven rats in group two and eight rats in group three received daptomycin and vancomycin, respectively. Microbiological and histological assessments were carried out on rats with induced infections. In the swab cultures of deep surgical areas, vancomycin demonstrated inhibition of infection of the surgical site in half of animals (50%) whereas daptomycin exhibited the same effect in more animals (71.4%), which was statistically significant compared to the control group (p<0.05). In the implant and bone culture, a statistically significant superiority was not observed in prophylactically treated with either antibiotic and nontreated control group (p>0.05). As a result; comparing control group, preventive effects of daptomycin and vancomycin in infection induced model of spinal implantation with high bacteria inoculums were not found statistically significant whereas daptomycin showed statistically significant inhibition on deep surgical area infection.en_US
dc.identifier.endpage775en_US
dc.identifier.issn1302-1664
dc.identifier.issn1302-1664en_US
dc.identifier.issue4en_US
dc.identifier.startpage767en_US
dc.identifier.urihttps://hdl.handle.net/11454/47919
dc.identifier.volume30en_US
dc.identifier.wosWOS:000335224200018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal of Neurological Sciences-Turkishen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDaptomycinen_US
dc.subjectinfectionen_US
dc.subjectspinal implantationen_US
dc.subjectvancomycinen_US
dc.titleA Study on Prophylactic Efficacies of Daptomycin and Vancomycin in a Rat Model of MRSA Infection Secondary to Spinal Implantationen_US
dc.typeArticleen_US

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