Distribution of I-131-labeled recombinant human erythropoietin in maternal and fetal organs following intravenous administration in pregnant rats

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dc.contributor.authorYilmaz, O.
dc.contributor.authorLambrecht, F. Y.
dc.contributor.authorGokmen, N.
dc.contributor.authorErbayraktar, S.
dc.contributor.authorDurkan, K.
dc.date.accessioned2019-10-27T19:33:12Z
dc.date.available2019-10-27T19:33:12Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of the present study was to demonstrate the possible transplacental transmission of I-131 labeled recombinant human erythropoietin (I-131-rh-EPO) in pregnant rats and its distribution through maternal and fetal organs. Six Wistar Albino Rats in their pregnancy of 18 days were used I-131 labeled recombinant human erythropoietin (specific activity = 2.4 mu Ci/IU) was injected into the tail vein of rats. After 30 minutes labeled erythropoietin infusion maternal stomach, kidney, lung, liver, brain and heart as well as fetus were removed. Then, the same organs were removed from each fetus. Measuring weight of maternal and fetal organs as well as placenta were followed by radioactivity count via Cd(Te) detector. I-131 labeled recombinant human erythropoietin was found to be able to pass rat placenta and its distribution order in fetal organs was similar to those of maternal organs. Besides, as measurements were performed closer to cornu uteri, uptakes were decreasing in every fetus and its corresponding placenta.en_US
dc.identifier.doi10.1007/s10967-007-6859-y
dc.identifier.endpage313en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue2en_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-007-6859-y
dc.identifier.urihttps://hdl.handle.net/11454/39431
dc.identifier.volume273en_US
dc.identifier.wosWOS:000248003400008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleDistribution of I-131-labeled recombinant human erythropoietin in maternal and fetal organs following intravenous administration in pregnant ratsen_US
dc.typeArticleen_US

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