Distribution of zinc and copper in thiocyanate administered rats
Küçük Resim Yok
Tarih
1998
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Libbey Eurotext
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Smoking, a form of cyanide exposure influences the in vivo elemental status. Considering the complex interactions between anions and the cellular traffic of vital trace elements, in this study the relationship between-thiocyanate (SCN-) the major metabolite of cyanide, which is an anion and the in vivo distribution of copper (Cu) and zinc (Zn) is investigated. Swiss albino male rats were divided into three groups. Group A (n=10) and group B (n=10) received subcutaneously 60 mg/kg/day and 120 mg/kg/day SCN- respectively for 15 days. Saline was injected to the control group (n=10) at the same period. After drawing blood for SCN- analysis, rats were decapitated. Hepatic, renal, myocardial and skeletal muscle specimens were wet digested with nitric: sulphuric: perchloric acid (3:1:1) (v:v:v). Tissue Cu and Zn were determined by ICP-AES, and plasma SCN- by colorimetry. Plasma SCN-was significantly elevated in both group A (p< 0.05, 30.34 +/- 7.44 mu mol/L) and group B (p<0.01, 104.14 +/- 17.48 mu mol/L) compared to the controls (28.45 +/- 5.78 mu mol/L). As to the Cu and Zn content of the tissues analysed, no significant variations could be detected in the SCN- treated rats with respect to myocardial and renal tissues. On the contrary, hepatic Cu was elevated in both groups (p<0.01) with a similar pattern in skeletal muscle (p<0.05, in group A; p<0.01, in group B). An increase in Zn could only be noted in skeletal muscle of group B (p< 0.01). This study implies that SCN- has to some extent an effect in the in vivo distribution of Cu and Zn.
Açıklama
5th International Symposium on Metal Ions in Biology and Medicine -- MAY 08-10, 1998 -- NEUHERBERG, GERMANY
Anahtar Kelimeler
Kaynak
Metal Ions in Biology and Medicine, Vol 5
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
5
