Structural connectivity in adolescent synthetic cannabinoid users with and without ADHD

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dc.contributor.authorÇelik Z.Ç.
dc.contributor.authorÇolak Ç.
dc.contributor.authorDi Biase M.A.
dc.contributor.authorZalesky A.
dc.contributor.authorZorlu N.
dc.contributor.authorBora E.
dc.contributor.authorKitiş Ö.
dc.contributor.authorYüncü Z.
dc.date.accessioned2019-10-26T21:14:05Z
dc.date.available2019-10-26T21:14:05Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractSynthetic cannabinoids (SC) have become increasingly popular in the last few years, especially among adolescents. Given ADHD is overrepresented in patients with substance use across adolescents compared to the general population, the current study aims were two-fold: i) examine structural brain network topology in SC users compared to healthy controls and, ii) examine the influence of ADHD on network topology in SC users. Diffusion-weighted magnetic resonance imaging scans were acquired from 27 SC users (14 without ADHD and 13 with ADHD combined type) and 13 controls. Structural networks were examined using network-based statistic and connectomic analysis. We found that SC users without ADHD had significantly weaker connectivity compared to controls in bilateral hemispheres, most notably in edges connecting the left parietal and occipital regions. In contrast, SC users with ADHD showed stronger structural connectivity compared to controls. In addition, adolescent SC users with ADHD, but not without ADHD, displayed reduced network organization, indicated by lower clustering coefficient and modularity, suggesting that poor structural network segregation and preserved structural network integration. These results suggest that comorbidity of ADHD and substance dependence may show different structural connectivity alterations than substance use alone. Therefore, future connectivity studies in the substance use population should account for the presence of ADHD in their samples, which may be associated with disparate connectivity profiles. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.identifier.doi10.1007/s11682-018-0023-x
dc.identifier.issn1931-7557
dc.identifier.issn1931-7557en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s11682-018-0023-x
dc.identifier.urihttps://hdl.handle.net/11454/15834
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer New York LLCen_US
dc.relation.ispartofBrain Imaging and Behavioren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectADHDen_US
dc.subjectConnectomicsen_US
dc.subjectStructural connectivityen_US
dc.subjectSynthetic cannabinoidsen_US
dc.subjectWhite matteren_US
dc.titleStructural connectivity in adolescent synthetic cannabinoid users with and without ADHDen_US
dc.typeArticleen_US

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