Focusing on the Optimization for Scale up in Airlift Bioreactors and the Production of Chlamydomonas reinhardtii as a Model Microorganism

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dc.contributor.authorOncel, Suphi
dc.date.accessioned2019-10-27T22:05:53Z
dc.date.available2019-10-27T22:05:53Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this work is to use optimization as a tool for scale up in airlift bioreactors and apply this approach to a real life process. To put this approach into practice, Chlamydomonas reinhardtii, a green microalgae, was used as a model microorganism. The effects of the design parameters on the performance of the bioreactors were monitored through the changes in mixing and circulation times. As the first step, the effective parameters (draft tube diameter and height, water level over the draft tube, volumetric flow rate of air, and sparger-draft tube distance) in the 1.1 L airlift bioreactor were determined and optimized by the 5-factor, 3-level Box-Behnken design for response surface methodology. A draft tube with a 38-250 mm dimension was selected resulting in a mixing time of 9.94 s with a 1.05 L min(-1) air flow rate. In the second step the optimized values were applied to a larger airlift bioreactor of 11 L for C. reinhardtii productions. Comparable biomass productivities (0.87-0.90 g L-1 day(-1)) and doubling times (25-27 h) in both systems was a good indication of the success of the scale-up approach.en_US
dc.identifier.doi10.5053/ekoloji.2014.903
dc.identifier.endpage32en_US
dc.identifier.issn1300-1361
dc.identifier.issn1300-1361en_US
dc.identifier.issue90en_US
dc.identifier.startpage20en_US
dc.identifier.urihttps://doi.org/10.5053/ekoloji.2014.903
dc.identifier.urihttps://hdl.handle.net/11454/48633
dc.identifier.volume23en_US
dc.identifier.wosWOS:000336887900003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherFoundation Environmental Protection & Research-Fepren_US
dc.relation.ispartofEkolojien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAirlift Bioreactorsen_US
dc.subjectChlamydomonas reinhardtiien_US
dc.subjectMicroalgaeen_US
dc.subjectScale-Upen_US
dc.titleFocusing on the Optimization for Scale up in Airlift Bioreactors and the Production of Chlamydomonas reinhardtii as a Model Microorganismen_US
dc.typeArticleen_US

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