Trends in heart failure between 2016 and 2022 in Türkiye (TRends-HF): a nationwide retrospective cohort study of 85 million individuals across entire population of all ages

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dc.authorscopusid57200233149
dc.authorscopusid6603790014
dc.authorscopusid57218563931
dc.authorscopusid56801853200
dc.authorscopusid6507642303
dc.authorscopusid24471549000
dc.authorscopusid56550044500
dc.contributor.authorCelik, A.
dc.contributor.authorUral, D.
dc.contributor.authorSahin, A.
dc.contributor.authorColluoglu, I.T.
dc.contributor.authorKanik, E.A.
dc.contributor.authorAta, N.
dc.contributor.authorArugaslan, E.
dc.date.accessioned2024-08-25T18:51:46Z
dc.date.available2024-08-25T18:51:46Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Data on the burden of heart failure (HF) outside western countries are limited, but available data suggest it may present differently in other countries. The aim of this study was to examine the incidence, prevalence, and survival rates of HF in Türkiye, with a specific focus on how these rates vary according to age, sex, comorbidities, and socioeconomic status (SES). Methods: We harnessed the extensive National Electronic Database of the Turkish Ministry of Health, covering Turkey's entire population from January 1, 2016, to December 31, 2022, to identify 2,722,151 cases of HF and their associated comorbidities using ICD-10 codes. Analyzing the primary endpoint of all-cause mortality, our study utilized anonymized data to examine patient demographics, comorbidities, socioeconomic status, and survival patterns, employing statistical techniques to delve into relationships and trends. The data were segmented by gender, socioeconomic status, and age, involving cross-tabulations and statistical metrics to explore connections, odds ratios, and survival rates. Findings: The estimated prevalence of HF was 2.114% in Türkiye at the end of 2022, with an annual incidence ranging between 3.00 and 6.06 per 1000 person years. Females were older than males (69.8 ± 13.9 years vs. 66.8 ± 13.9 years, respectively). The most common comorbidities were congenital heart diseases and anemia under the age of 20, and hypertension and atherosclerotic cardiovascular disease in the adult population. Only 23.6% (643,159/2,722,151) of patients were treated with any triple guideline-directed medical therapy (GDMT) and 3.6% (96,751/2,722,151) of patients were on quadruple GDMT. The survival rates for patients with HF at 1, 5, and 7 years were 83.3% (95% CI: 83.2–83.3), 61.5% (95% CI: 61.4–61.6), and 57.7% (95% CI: 57.6–57.8) among females, and 82.1% (95% CI: 82.0–82.2), 58.2% (95% CI: 58.1–58.3), and 54.2% (95% CI: 54.0–54.3) among males. Despite a tendency for an increase from the highest to the lowest SES, the prevalence of HF and mortality were paradoxically lowest in the lowest SES region. Interpretation: The prevalence, incidence, and survival rates of HF in Türkiye were comparable to western countries, despite the notable difference of HF onset occurring 8–10 years earlier in the Turkish population. Drug usage statistics indicate there is a need for effective strategies to improve treatment with GDMT. Funding: None. © 2023 The Author(s)en_US
dc.description.sponsorshipNone.en_US
dc.identifier.doi10.1016/j.lanepe.2023.100723
dc.identifier.issn2666-7762
dc.identifier.scopus2-s2.0-85172238886en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.lanepe.2023.100723
dc.identifier.urihttps://hdl.handle.net/11454/102708
dc.identifier.volume33en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofThe Lancet Regional Health - Europeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectElectronic health recordsen_US
dc.subjectEpidemiologyen_US
dc.subjectHeart failureen_US
dc.subjectMortalityen_US
dc.subjectPrevalenceen_US
dc.subjectSocioeconomic statusen_US
dc.subjectangiotensin receptor antagonisten_US
dc.subjectbrain natriuretic peptideen_US
dc.subjectgalectin 3en_US
dc.subjectsodium glucose cotransporter 2 inhibitoren_US
dc.subjectacute heart infarctionen_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectall cause mortalityen_US
dc.subjectanonymised dataen_US
dc.subjectArticleen_US
dc.subjectbrain hemorrhageen_US
dc.subjectcardiac resynchronization therapyen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectcardiovascular risken_US
dc.subjectchronic obstructive lung diseaseen_US
dc.subjectcohort analysisen_US
dc.subjectcongenital heart diseaseen_US
dc.subjectcoronary atherosclerosisen_US
dc.subjectdilated cardiomyopathyen_US
dc.subjectechocardiographyen_US
dc.subjectelectronic health recorden_US
dc.subjectestimated glomerular filtration rateen_US
dc.subjectfemaleen_US
dc.subjectgenderen_US
dc.subjectglomerulus filtration rateen_US
dc.subjecthealth care costen_US
dc.subjecthealth insuranceen_US
dc.subjectheart failureen_US
dc.subjectheart transplantationen_US
dc.subjecthospital mortalityen_US
dc.subjecthospitalizationen_US
dc.subjecthumanen_US
dc.subjecthypertensionen_US
dc.subjecthyperthyroidismen_US
dc.subjecthypothyroidismen_US
dc.subjectICD-10en_US
dc.subjectincidenceen_US
dc.subjectlength of stayen_US
dc.subjectlife expectancyen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectmortalityen_US
dc.subjectmortality rateen_US
dc.subjectmulticenter study (topic)en_US
dc.subjectoverall survivalen_US
dc.subjectpercutaneous coronary interventionen_US
dc.subjectprevalenceen_US
dc.subjectretrospective studyen_US
dc.subjectsex differenceen_US
dc.subjectsocial statusen_US
dc.subjectsocial supporten_US
dc.subjectsurvival rateen_US
dc.subjecttrend studyen_US
dc.subjectTurk (people)en_US
dc.subjectTurkey (republic)en_US
dc.titleTrends in heart failure between 2016 and 2022 in Türkiye (TRends-HF): a nationwide retrospective cohort study of 85 million individuals across entire population of all agesen_US
dc.typeArticleen_US

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