Sodium nitroprusside metabolism during hypothermic cardiopulmonary bypass

Basit Öğe Kaydı
dc.contributor.authorAskar F.Z.
dc.contributor.authorKayaalti B.
dc.contributor.authorGuner I.
dc.contributor.authorTurkoglu M.
dc.contributor.authorYetginer A.
dc.contributor.authorCertug A.
dc.date.accessioned2019-10-27T00:34:10Z
dc.date.available2019-10-27T00:34:10Z
dc.date.issued1993
dc.departmentEge Üniversitesien_US
dc.description.abstractTo prevent the systemic vascular resistance increase during cardiopulmonary bypass (CPB), sodium nitroprusside (SNP) was used at infusion rates as suggested in normothermia (0.5-8 µg/kg/min) in randomly selected 16 patients undergoing coronary artery bypass grafting (CABG). SNP infusion was started when mean arterial blood pressure (MAP) increased over 80 mmHg and continued until it decreased to 60 mmHg. The mean SNP doses and infusion rates and related blood cyanide (CN-) levels were measured in 10 patients and plasma thiocyanate (SCN-) levels in 16 patients before, during and after hypothermia. At the beginning of CPB, but before SNP infusion, blood CN- and plasma SCN levels are 0.437 ± 0.05 µmol/L and 0.250 ± 0.02 mg/dl respectively. At 28°C, blood CN- level was 0.712 ± 0.15 µmol/L and plasma SCN- level was 0.313 ± 0.03 mg/dl. At the end of hypothermia, they were 1.468 ± 0.29 µmol/L and 0.405 ± 0.04 mg/dl respectively. The highest blood CN- level observed was in the third blood sample (1.468 ± 0.29) taken at the end of hypothermia. The peak plasma SCN level was reached (0.623 ± 0.12) four hours after rewarming. No patient showed toxicity symptoms and blood levels never reached to toxic levels. In conclusion, SNP can be used safely at infusion rates as suggested in normothermia in CPB. But especially in prolonged hypothermia CPB, the risk of CN-toxicity must be considered and metabolic status of the patient must be examined carefully.en_US
dc.identifier.endpage85en_US
dc.identifier.issn1016-5150
dc.identifier.issn1016-5150en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage81en_US
dc.identifier.urihttps://hdl.handle.net/11454/24200
dc.identifier.volume21en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleSodium nitroprusside metabolism during hypothermic cardiopulmonary bypassen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu