Interaction between green tea extract and Tc-99m-pertechnetate on in vivo distribution

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dc.contributor.authorSabuncu, Burak
dc.contributor.authorMuftuler, Fazilet Zumrut Biber
dc.contributor.authorKilcar, Ayfer Yurt
dc.contributor.authorCekic, Betul
dc.contributor.authorUcar, Eser
dc.contributor.authorUnak, Perihan
dc.date.accessioned2019-10-27T22:14:52Z
dc.date.available2019-10-27T22:14:52Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractPeople drink various types of tea without knowing the side effects of biological and chemical contents and radiopharmaceutical interactions. In current study, it is aimed to evaluate the effects of green tea extract in different extraction solvents on the radiolabeling of the blood constituents with Tc-99m and on the biodistribution of radiopharmaceutical sodium pertechnetate ((NaTcO4)-Tc-99m) in male Wistar Albino rats. The extraction of green tea was performed in different solvents. Biodistribution studies were performed on male rats which were treated via gavage with green tea extract in different extraction solvents or saline (0.9 % NaCl) as a control group for 7 days. The radiolabeling of blood constituents performed incubating with SnCl2 and Tc-99m. According to experimental results, radiolabeling blood components with Tc-99m were not modified in the usage of the different extraction solvents for green tea extraction, but a significant alteration (P < 0.05) of biodistribution of (NaTcO4)-Tc-99m was observed after treatment with green tea extract in distilled water. Although there is no considerable effect on radiolabeling of blood components, there is an outstanding change on the biodistribution studies especially with green tea extract in distilled water. The identified change monitored in this study may cause to reduce the risk of misdiagnosis and/or avoid the repetition of the examinations in nuclear medicine.en_US
dc.identifier.doi10.1007/s10967-014-3089-y
dc.identifier.endpage1026en_US
dc.identifier.issn0236-5731
dc.identifier.issn1588-2780
dc.identifier.issn0236-5731en_US
dc.identifier.issn1588-2780en_US
dc.identifier.issue3en_US
dc.identifier.startpage1021en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-014-3089-y
dc.identifier.urihttps://hdl.handle.net/11454/50084
dc.identifier.volume300en_US
dc.identifier.wosWOS:000335673800015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGreen teaen_US
dc.subjectCatechinen_US
dc.subjectTc-99m-pertechnetateen_US
dc.subjectBlood cellsen_US
dc.subjectBiodistributionen_US
dc.titleInteraction between green tea extract and Tc-99m-pertechnetate on in vivo distributionen_US
dc.typeArticleen_US

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