Evaluation of insulin resistance by the homeostasis model assessment in female patients with Primary Sjogren's Syndrome

Küçük Resim Yok

Tarih

2011

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Objective: To evaluate insulin resistance in Primary Sjogren's Syndrome (pSS) using homeostasis model assessment (HOMA) method Design: Cross-sectional study conducted between January 2006 and December 2008 Setting: Ege University Faculty of Medicine, Izmir, Turkey Subjects: Thirty-fivefemalepatientswithpSSfulfillingtheUS-European Consensus Criteria Interventions: A brief clinical history, demographic, anthropometric, clinical and laboratory profileswererecorded Main Outcome Measures: HOMA-IR and serum lipid levels Results: Mean level of HOMA-IR was 1.8 ± 0.7 in patients with pSS. Mean levels of plasma fasting glucose and insulin were 90.6 ± 7.1 mg/dl, 7.8 ± 2.5 microU/l, respectively. A statistically significantdifferencewasdetectedbetweenANA positivity and HOMA-IR values (p = 0.016). Four patients with pSS had high HOMA values (> 2.7) and all these patients had ANA positivity. A statistically significantpositive correlation was detected between HOMA-IR values and HDL-C levels (R = 0,450 p = 0.009). However, a statistically significantdifferencewasdetectedbetweenextraglandularinvolvement and LDL-C (p = 0.01) and total cholesterol levels (p = 0.01). Patients who had no extraglandular involvement had higher levels of total cholesterol and LDL-C levels. Lower triglyceride levels were seen in patients with anti-La antibodies (p = 0.01) but not other antibodies (p > 0.05). Patients with ANA positivity and pSS had lower LDL-C levels (p = 0.009). Conclusion: Autoimmune mechanisms may play a role in insulin resistance in pSS. Metabolic alterations should be taken into account in their management.

Açıklama

Anahtar Kelimeler

HOMA, Insulin resistance, Sjogren's syndrome

Kaynak

Kuwait Medical Journal

WoS Q Değeri

Scopus Q Değeri

N/A

Cilt

43

Sayı

3

Künye