In-Vitro-Response of Platelet Aggregation Induced by Various Agonists in Chronic Smoking Coronary Artery Disease Patients

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dc.contributor.authorSagcan A.
dc.contributor.authorNalbantgil S.
dc.contributor.authorSekuri C.
dc.contributor.authorOmay S.B.
dc.contributor.authorAkin M.
dc.date.accessioned2019-10-27T00:23:05Z
dc.date.available2019-10-27T00:23:05Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Chronic cigarette smoking (CCS) is known as one of the major risk factors in the development of atherosclerosis. The relationship between smoking and coronary artery disease (CAD) has been established by epidemiological studies. Smoking has also been shown to have negative effects on haemostatic balance especially on platelet function. Aim: In this study, the effect of CCS on in-vitro-platelet-aggregation induced by various agonists was investigated in coronary artery disease patients. Methods: One hundred and twenty-one patients with stable angina pectoris and controlled unstable angina pectoris were included in the study. Patients were divided into two groups: Group I consisted of 53 CCS patients and Group II consisted of 68 non-smokers. Agonist induced platelet aggregation (PA) waves were measured by turbidometric method of Born. Maximum amplitude and duration of aggregation waves for each of the agonists were calculated. Results: Maximum amplitude and duration of ADP, collagen, and epinephrine induced in vitro PA response were significantly higher in Group I (p-values respectively: p < 0.05, p < 0.0001, p < 0.0001). Conclusion: In vitro PA response is increased despite antiaggregant therapy in CAD patients who are chronic smokers. Further studies are needed to establish the effect of smoking cessation on PA and progression of CAD. We also believe that prospective studies are needed to show the effect of more efficient antiaggregant therapy for CAD patients who are chronic smokers.en_US
dc.identifier.endpage57en_US
dc.identifier.issn1561-2775
dc.identifier.issn1561-2775en_US
dc.identifier.issue01.Apren_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage55en_US
dc.identifier.urihttps://hdl.handle.net/11454/22722
dc.identifier.volume6en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Clinical and Basic Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgonistsen_US
dc.subjectCoronary artery diseaseen_US
dc.subjectIn vitro platelet aggregationen_US
dc.subjectSmokingen_US
dc.titleIn-Vitro-Response of Platelet Aggregation Induced by Various Agonists in Chronic Smoking Coronary Artery Disease Patientsen_US
dc.typeArticleen_US

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