Chimerism Analysis of Children with Allogeneic Stem-Cell transplantation and Its Effect on Survival

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dc.authoridTekguc, Hakan/0000-0001-6424-6761
dc.contributor.authorTekguc, Hakan
dc.contributor.authorAksoylar, Serap
dc.contributor.authorTekguc, Doga Ceren
dc.contributor.authorKansoy, Savas
dc.date.accessioned2023-01-12T20:16:32Z
dc.date.available2023-01-12T20:16:32Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractBACKGROUND/AIMS: Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is an important and usually the only curative clinical tool for treating pediatric patients with many hereditary and acquired diseases. Although complete donor stem cell engraftment is the desired result of Allo-HSCT, patients do not always have a definite engraftment and end up with mixed chimerism. Many factors both related to patient and transplantation can affect chimerism levels. Additionally, mixed chimerism levels may affect the event free survival (EFS) differently in distinct diseases. The major goals of this study were to determine the first 100-day donor chimerism ratios and to search for a relationship between donor chimerism success (CS) (for malignant diseases, hematopoietic donor chimerism >95%; for non-malignant diseases, >70%) and EFS for pediatric patients.MATERIALS AND METHODS: We collected data from 95 pediatric patients who underwent Allo-HSCT between March, 2005 and April, 2010 at Ege University Hospital with at least one chimerism result obtained within the first 100 days.RESULTS: After checking for all other factors, CS in the first 100 days increases the chance of post-transplant EFS by-3.04 (-4.00 to-2.08) [hazard ratio (HR): 0.05 (p<0.001)]. Neutrophil engraftment was the other factor which was positively correlated with EFS (HR p-value: 0.05)CONCLUSION: There is a positive correlation between CS in the first 100 days and EFS for both malignant and non-malignant diseases.en_US
dc.identifier.doi10.4274/cjms.2022.2021-215
dc.identifier.endpage668en_US
dc.identifier.issn2149-7893
dc.identifier.issn2536-507X
dc.identifier.issn2149-7893en_US
dc.identifier.issn2536-507Xen_US
dc.identifier.issue5en_US
dc.identifier.startpage664en_US
dc.identifier.urihttps://doi.org/10.4274/cjms.2022.2021-215
dc.identifier.urihttps://hdl.handle.net/11454/78732
dc.identifier.volume7en_US
dc.identifier.wosWOS:000886060300016en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofCyprus Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildrenen_US
dc.subjectchimerismen_US
dc.subjectstem -cell -transplantationen_US
dc.subjectAcute Lymphoblastic-Leukemiaen_US
dc.subjectHematopoietic Scten_US
dc.subjectMixed Chimerismen_US
dc.subjectFemale Donorsen_US
dc.subjectThalassemiaen_US
dc.titleChimerism Analysis of Children with Allogeneic Stem-Cell transplantation and Its Effect on Survivalen_US
dc.typeArticleen_US

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