The Comparison of Electrochemical Assay and Agarose Gel Electrophoresis for the Determination of DNA Damage Induced by Kainic Acid

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dc.contributor.authorKaradeniz, Hakan
dc.contributor.authorArmagan, Guliz
dc.contributor.authorErdem, Arzum
dc.contributor.authorTurunc, Ezgi
dc.contributor.authorCaliskan, Ayfer
dc.contributor.authorKanit, Lutfiye
dc.contributor.authorYalcin, Ayfer
dc.date.accessioned2019-10-27T20:48:24Z
dc.date.available2019-10-27T20:48:24Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractA possible DNA damage after interaction of kainic acid (KA) with calf thymus double stranded DNA and genomic DNA was herein determined in in vitro and in vivo conditions using; electrochemical assay and agarose gel electrophoresis. The changes in guanine signal were detected as an indicator of DNA damage in genomic DNA samples isolated from 1 or 10 mg/kg KA-treated animals. The decreased levels of guanine signal were found as 29% and 33% by 1 and 10 mg/kg KA treatment when compared to controls, respectively. The results of gel electrophoresis confirmed DNA damage obtained in identical samples by electrochemical method.en_US
dc.description.sponsorshipTurkish Scientific and Technological Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1045280, 106S181]en_US
dc.description.sponsorshipAuthors thank for the financial support from Turkish Scientific and Technological Council (TUBITAK; Project no. 1045280 and 106S181). A. E., an associate member of Turkish Academy of Sciences (TUBA), expresses her gratitude to the TUBA for their support. G. A, E. T and A. C acknowledge their scholarships to TUBITAK.en_US
dc.identifier.doi10.1002/elan.200900218
dc.identifier.endpage2476en_US
dc.identifier.issn1040-0397
dc.identifier.issn1521-4109
dc.identifier.issn1040-0397en_US
dc.identifier.issn1521-4109en_US
dc.identifier.issue22en_US
dc.identifier.startpage2468en_US
dc.identifier.urihttps://doi.org/10.1002/elan.200900218
dc.identifier.urihttps://hdl.handle.net/11454/42704
dc.identifier.volume21en_US
dc.identifier.wosWOS:000272390100010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofElectroanalysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDNA damageen_US
dc.subjectKainic aciden_US
dc.subjectElectrochemical sensor technologyen_US
dc.subjectAgarose gel electrophoresisen_US
dc.subjectGuanine signalen_US
dc.subjectDNA damageen_US
dc.subjectElectrophoresisen_US
dc.titleThe Comparison of Electrochemical Assay and Agarose Gel Electrophoresis for the Determination of DNA Damage Induced by Kainic Aciden_US
dc.typeArticleen_US

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