Elevated levels of matrix metalloprotein-3 in patients with coronary aneurysm: A case control study

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dc.contributor.authorTengiz I.
dc.contributor.authorErcan E.
dc.contributor.authorAliyev E.
dc.contributor.authorSekuri C.
dc.contributor.authorDuman C.
dc.contributor.authorAltuglu I.
dc.date.accessioned2019-10-27T00:13:13Z
dc.date.available2019-10-27T00:13:13Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of arterial aneurysms through increased proteolysis of extracellular matrix proteins. Increased proteolysis due to elevated matrix degrading enzyme activity in the arterial wall may act as a susceptibility factor for the development of coronary aneurysms. The aim of this study was to investigate the association between MMPs and presence of coronary aneurysms. Methods: Thirty patients with aneurysmal coronary artery disease and stable angina were enrolled into study (Group 1). Fourteen coronary artery disease patients with stable angina were selected as control group (Group 2). MMP-1, MMP-3 and C-reactive protein (CRP) were measured in peripheral venous blood and matched between the groups. Results: Serum MMP-3 level was higher in patients with aneurismal coronary artery disease compared to the control group (20.23 ± 14.68 vs 11.45 ± 6.55 ng/ml, p = 0.039). Serum MMP-1 (13.63 ± 7.73 vs 12.15 ± 6.27 ng/ml, p = 0.52) and CRP levels (4.78 ± 1.47 vs 4.05 ± 1.53 mg/l, p = 0.13) were not significantly different between the groups. Conclusion: MMPs can cause arterial wall destruction. MMP-3 may play role in the pathogenesis of coronary aneurysm development through increased proteolysis of extracellular matrix proteins. © 2004 Tengiz et al; licensee BioMed Central Ltd.en_US
dc.identifier.doi10.1186/1468-6708-5-10
dc.identifier.issn1468-6694
dc.identifier.issn1468-6694en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1186/1468-6708-5-10
dc.identifier.urihttps://hdl.handle.net/11454/22440
dc.identifier.volume5en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofCurrent Controlled Trials in Cardiovascular Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleElevated levels of matrix metalloprotein-3 in patients with coronary aneurysm: A case control studyen_US
dc.typeArticleen_US

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