Relationship of oxygen delivery and consumption during short term dobutamine infusion in septic and non-septic patients [Septik ve septik olmayan hastalarda kisa sureli dobutamin uygulamasinda oksijen sunumu - Tuketimi iliskisi]
Küçük Resim Yok
Tarih
1998
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study it was aimed to compare the increase in oxygen consumption in response to the increase in oxygen delivery after short term infusion of dobutamine in two groups of patients including 10 septic (Group I) and 9 non- septic (Group II) patients in our Reanimation Clinic. Both groups patients are elected from patients who had neuromuscular blockade, sedation and mechanical ventilatory support for acute respiratory failure, the septic group consisted of the patients having the two or more of the sepsis criteria. After maintaining standard monitoring the heart rate, MAP, MPAP, PCWP, CVP, Q measurements and arterial and mixed venous blood gas analysis together with CaO2, CvO2, a-vDO2, DO2, VO2, ERO2 calculations were performed. The measurements before the dobutamine infusion were recorded as the control values and the measurements were repeated after 30 minutes infusion of 3 µg/kg/min dobutamine and again after another 30 minutes infusion of 6 µg/kg/min infusion of dobutamine, in the septic group, the DO2 values increased from baseline values 954±192 mL/min/m2 to 1185±195 and to 1360±199 mL/min/m2 (p<0.01), and VO2 values increased from 246±41 mL/min/m2 to 1185±195 and to 1360±199 mL/min/m2 (p<0.01), and VO2 values increased from 246±41 mL/min/m2 to 1185±195 and to 1360±199 mL/min/m2 (p<0.01), and VO2 values increased from 246±41 mL/min/m2 to 270±45 and to 283±48 mL/min/m2 (p<0.05) respectively. In the septic group, DO2 values, increased from 940±222 mL/min/m2 to 1255±216 mL/min/m2 and to 1361±230 mL/min/m2 (p<0.01) and VO2 values increased from 269±50 mL/min/m2 mL/min/m2 and to 294±50 mL/min/m2 to 302±75 mL/min/m2 mL/min/m2 and to 294±47 mL/min/m2 (p<0.05) respectively. The DO2 increase in both groups were similar after the infusion dose was increased to 6 µg/kg/min, whereas the VO2 values in the non-septic group decreased without statistical significance when compared to the septic group (p>0.05). As a result lineer relation 'pathological oxygen delivery-consumption relationship' in the septic group and biphasix relation 'physiological oxygen delivery-consumption relationship' was found in the septic group.
Açıklama
Anahtar Kelimeler
Dobutamine, Oxygen consumption, Oxygen delivery, Sepsis
Kaynak
Turk Anesteziyoloji ve Reanimasyon
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
26
Sayı
8
