Labeling of famotidine with Tc-99m and biodistribution studies on rats

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dc.contributor.authorUnak, P
dc.contributor.authorLambrecht, FY
dc.contributor.authorBiber, FZ
dc.contributor.authorMedine, IE
dc.contributor.authorTeksoz, S
dc.date.accessioned2019-10-27T18:37:32Z
dc.date.available2019-10-27T18:37:32Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractFamotidine, a gastrointestinal drug was labeled with Tc-99m and its radiopharmaceutical potential was observed on male Albino Wistar rats. Labeling yield was over 95%. Average specific activity and n-octanol/water partition coefficient (lipophilicity) were approximately 74 MBq/mg-0.66 GBq/mg and 3.4, respectively. Biodistribution studies were performed on Albino Wistar rats. The activity per gram tissue was calculated and time activity curves were generated. The majority of the activity was observed in stomach, small intestines and kidneys. Liver and kidneys showed lower uptake compared to other H-2-receptor rich tissues. Results show that Tc-99m-famotidine is H-2 receptor specific.en_US
dc.identifier.doi10.1023/B:JRNC.0000037099.75789.29
dc.identifier.endpage591en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue3en_US
dc.identifier.startpage587en_US
dc.identifier.urihttps://doi.org/10.1023/B:JRNC.0000037099.75789.29
dc.identifier.urihttps://hdl.handle.net/11454/36427
dc.identifier.volume261en_US
dc.identifier.wosWOS:000223119100012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKluwer Academic Publen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleLabeling of famotidine with Tc-99m and biodistribution studies on ratsen_US
dc.typeArticleen_US

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