ANTIBACTERIAL RESISTANCE PATTERNS AND INCIDENCE OF NOSOCOMIAL PSEUDOMONAS AERUGINOSA BACTEREMIA IN A TERTIARY-CARE EDUCATIONAL HOSPITAL IN TURKEY: A PERSPECTIVE BETWEEN 2001 AND 2019

Basit Öğe Kaydı
dc.authoridUysal, Serhat/0000-0002-4294-5999
dc.authoridKaratas, Mustafa/0000-0002-2464-0593
dc.authorscopusid57199151189
dc.authorscopusid57226767083
dc.authorscopusid8905840200
dc.authorscopusid54685430400
dc.authorscopusid15726062200
dc.authorscopusid55664567200
dc.authorscopusid6602210366
dc.authorwosidUysal, Serhat/AAB-4876-2021
dc.authorwosidAkyol, Deniz/HGB-7894-2022
dc.authorwosidSipahi, Oguz Resat/AAR-2916-2020
dc.authorwosidKaratas, Mustafa/GQH-0977-2022
dc.contributor.authorAkyol, Deniz
dc.contributor.authorKaratas, Mustafa
dc.contributor.authorAydemir, Sohret
dc.contributor.authorUysal, Serhat
dc.contributor.authorPullukcu, Husnu
dc.contributor.authorTasbakan, Meltem
dc.contributor.authorTunger, Alper
dc.date.accessioned2023-01-12T20:11:33Z
dc.date.available2023-01-12T20:11:33Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractBackground: Pseudomonas aeruginosa (PSA) is one of the most important pathogens causing nosocomial bacteremia in most parts of the world. Objectives: In this study it was aimed to evaluate the resistance patterns and incidence of microbiologically confirmed nosocomial bacteremia (MCNB) related PSA strains between 2001-2019. Methods: Any patient in whom PSA was isolated in at least one set of blood cultures (sent to the bacteriology laboratory 72h after hospital admission) was considered to have microbiologically confirmed NB. Blood cultures were performed on Back/Alert (bioMerieux, Durham, NC). Bacterial identifications were performed by automated API (bioMerieux, Durham, NC). Antibacterial susceptibility tests were evaluated according to Clinical Laboratory Standards Institute (CLSI) criteria until 2014 and EUCAST between 2015 and 2019. Incidence density of PSA MCNB was calculated by using hospital electronic database. Results: A total of 1705 strains of P.aeruginosa fulfilling study inclusion criteria, were isolated during the 19-year study period in the hospital from intensive care units and clinics and included in the study. When the 2001-2002 and 2018-2019 periods were compared, there was a decrease in resistance to meropenem and amikacin (31.1%-20.4% p: 0.025 and 34.3%-22.8% p:0.029). However, the analysis of the resistance patterns of carbapenem-resistant P. aeruginosa strains as a subgroup (2001-2002) vs (2018 vs 2019), ciprofloxacin and cefepime resistance rates increased significantly (58%-79% p:0.0096 and 46%-72% p: 0.026). P. aeruginosa bacteremia rates incidence density rates ranged between 0.11 and 0.30 episodes per thousand hospital day during the study period. Conclusion: During the 19 years there was a significant decrease in amikacin and meropenem resistance while there was a significant increase in the subgroup of carbapenem-resistant strains. More infection control and antimicrobial stewardship efforts are needed to decrease the antibacterial resistance rates and incidence.en_US
dc.identifier.doi10.19193/0393-6384_2022_2_151
dc.identifier.endpage990en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issn0393-6384en_US
dc.identifier.issn2283-9720en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85128152308en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage985en_US
dc.identifier.urihttps://doi.org/10.19193/0393-6384_2022_2_151
dc.identifier.urihttps://hdl.handle.net/11454/78143
dc.identifier.volume38en_US
dc.identifier.wosWOS:000798951300035en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBacteremiaen_US
dc.subjectnosocomial Infectionen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectcarbapenem resistanceen_US
dc.subjectinfection controlen_US
dc.subjectAntimicrobial Resistanceen_US
dc.subjectSurveillanceen_US
dc.titleANTIBACTERIAL RESISTANCE PATTERNS AND INCIDENCE OF NOSOCOMIAL PSEUDOMONAS AERUGINOSA BACTEREMIA IN A TERTIARY-CARE EDUCATIONAL HOSPITAL IN TURKEY: A PERSPECTIVE BETWEEN 2001 AND 2019en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu