Multifunctional molecular imaging probes for estrogen receptors: 99mTc labeled diethylstilbestrol (DES) conjugated, cuinp quantum dot nanoparticles (DESCIP)

Küçük Resim Yok

Tarih

2017

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Springer Netherlands

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

A theranostic nanoparticle was synthesized based on diethylstilbestrol conjugated with phosphate, copper, and indium (DESCIP) and labelled with 99mTc which can be used for SPECT imaging of ER-enriched cancers. In vitro biological activity of 99mTc-DESCIP was examined in breast adenocarcinoma cells (MCF-7), prostatic carcinoma cells (PC-3), and pulmonary epithelial cells (A-549). In vivo lymph node imaging was performed in normal and receptor blocked female New Zealand rabbits. Results demonstrated that 99mTc-DESCIP and DESCIP has potential for imaging ER-enriched tumors such as breast and prostate tumors, and their metastases in the lung, as well as improving management for their therapies. © 2017, Akadémiai Kiadó, Budapest, Hungary.

Açıklama

Anahtar Kelimeler

Breast cancer, Cancer imaging, Diethylstilbestrol, Lung cancer, Prostate cancer, Quantum dot nanoparticles

Kaynak

Journal of Radioanalytical and Nuclear Chemistry

WoS Q Değeri

Scopus Q Değeri

Q2

Cilt

314

Sayı

3

Künye