In vitro evaluation of radiolabeled (I-125) methanol extracts of yarrow in cell lines of MCF-7, PC-3, A-549 and Caco-2
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Nowadays, cancer is still the second leading cause of death all over the world. Therefore, natural products which have anticancer and antitumor properties are come into prominence. Achillea family is known with anticancer and antitumor activity. Yarrow which has over a hundred bioactive compounds is a member of Achillea family. In current study; components of yarrow which was obtained after methanol extraction and purification were radiolabeled with I-125 and effects of these radiolabeled components on the cells were examined with using Caco-2, MCF-7, A-549, PC-3 cell lines. As a result of these studies, seven peaks were obtained and the highest radiolabeling yield was calculated for I-125 radiolabeled Peak 7 (95.00 +/- A 7.07, n = 4). To screen the biological properties of these radiolabeled peaks at determined cell lines, our ongoing effort was to evaluate incorporation percentage with time dependent. Furthermore, I-125-Peak 7 had highest incorporation ratio for whole cell lines and its incorporation percentage was increased with time dependent. Results of these in vitro studies were compatible with previous in vivo studies and traditional use of yarrow plants.
Açıklama
Anahtar Kelimeler
Methanol extraction of yarrow, Radiolabeled with I-125, Cell culture (MCF-7, PC-3, A-549, Caco-2 cell lines)
Kaynak
Journal of Radioanalytical and Nuclear Chemistry
WoS Q Değeri
Q1
Scopus Q Değeri
Cilt
295
Sayı
1
