Complement C1, C3 and C4 levels in sera of leishmaniasis cases in Turkey

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dc.contributor.authorLimoncu, M. E.
dc.contributor.authorSanlidag, T.
dc.contributor.authorBalcioglu, I. C.
dc.contributor.authorAkcali, S.
dc.contributor.authorOzensoy, S.
dc.contributor.authorOzbel, Y.
dc.date.accessioned2019-10-27T21:24:41Z
dc.date.available2019-10-27T21:24:41Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractLeishmaniasis is still a problem for many countries including developed ones. The subgroups of the serum complements have significant roles on the onset of the infection. The aim of this study was to determine the serum complement (C1, C3, C4) levels of cases with definite diagnosis of leishmaniasis and compare them with healthy controls. The study group included 43 visceral leishmaniasis (VL) and 13 cutaneous leishmaniasis (CL) cases. Two control groups were formed for the study. The first control group included 50 individuals of the same age group having no health complaints, admitted for routine control and found to be serologically negative. The second control group included 28 individuals, consistent with the diagnostic criteria of VL. The serum complement levels of C1, C3 and C4 were measured by the nephelometric method. The average levels of C1 were found to be high in VL cases (78.98%) and low in CL (41.69%) group, which was statistically significant (p=0.011). In addition, the average levels of C3 were high in CL group (96.08%) and low in VL group (62.00%), which was also statistically significant (p=0.010). C4 levels were found to be high in the control group, while similar in VL and CL groups. C1, C3, C4 levels were found to be lower in the first control group of healthy individuals. The levels of the subgroups of complement system show statistically significant in both VL and CL cases, which suggested that they could be useful in verifying the results of the serological examinations.en_US
dc.identifier.endpage724en_US
dc.identifier.issn1996-0808
dc.identifier.issn1996-0808en_US
dc.identifier.issue6en_US
dc.identifier.startpage720en_US
dc.identifier.urihttps://hdl.handle.net/11454/44626
dc.identifier.volume5en_US
dc.identifier.wosWOS:000293695300022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.relation.ispartofAfrican Journal of Microbiology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLeishmaniasisen_US
dc.subjectcomplement levelsen_US
dc.subjectC1en_US
dc.subjectC3en_US
dc.subjectC4en_US
dc.titleComplement C1, C3 and C4 levels in sera of leishmaniasis cases in Turkeyen_US
dc.typeArticleen_US

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