Assessment of antioxidant and neuroprotective activity of plants from the Lamiaceae family

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dc.authorid0000-0002-7445-5855
dc.authorid0000-0001-7882-0517
dc.authorid0000-0002-5094-9949
dc.authorid0000-0001-6466-2263
dc.authorid0000-0002-9194-3447
dc.authorid0000-0003-0913-5369
dc.authorid0000-0001-7645-1930
dc.contributor.authorFafal, Tugce
dc.contributor.authorKayalar, Husniye
dc.contributor.authorBirim, Dervis
dc.contributor.authorArmagan, Guliz
dc.contributor.authorTuzun, Burcu Sumer
dc.contributor.authorTastan, Pelin
dc.contributor.authorKivcak, Bijen
dc.date.accessioned2025-03-05T10:48:31Z
dc.date.available2025-03-05T10:48:31Z
dc.date.issued2024
dc.departmentEge Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Biyokimya Ana Bilim Dalı
dc.description.abstractBackground and Aims: Plants from the Lamiaceae family are shown to have pharmacological activities, including antiinflammatory, antidiabetic, antiasthmatic, hypolipidemic, antibacterial. This research measured the antioxidant and neuroprotective capacity of methanol extracts from the Mattubium vulgate L., Phlomis atmeniaca Willd., Thymus haussknechtii Velen. and, Thymus kotschyanus Boiss. & Hohen plants in cellular and cell-free systems. Methods: The neuroprotective potential of Mattubium vulgate, Phlomis atmeniaca, Thymus haussknechtii, and T. kotschyanus were determined against H2O2 toxicity in SH-SY5Y, the human neuroblastoma cell line. The antioxidant capacity of methanol extracts was examined by radical scavenging assays using static exempt chemical groups, 2.2'-diphenyl-1-picrylhydrazyl-hydrate (DPPH) and 2.2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). Folin-Ciocalteau and Aluminum chloride assays were used to measure phenolic and flavonoid contents of the extracts. Results: Following these experiments, the effect of three different concentrations of extracts (1, 10 and 100 mu g/mL) on cell viability was assessed by a WST-1 [2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium)]. The methanol extract of Mattubium vulgate was found to have the highest antiradical activity against DPPH (76.439 +/- 0.42%). The Thymus kotschyanus (10 mu g/mL) protected cells from H2O2-induced toxicity in all the extracts (p<0.05). Conclusion: In our report, we suggest that Thymus kotschyanus have potential neuroprotective activity because of the existence of polyphenolic compounds, flavonoids, and phenolic acids.
dc.identifier.citationFafal, T., Kayalar, H., Birim, D., Armağan, G., Sümer Tüzün, B., Taştan, P., & Kıvçak, B. (2024). Assessment of antioxidant and neuroprotective activity of plants from the lamiaceae family. Istanbul Journal of Pharmacy, 54(3), 403-408.
dc.identifier.doi10.26650/IstanbulJPharm.2024.1099972
dc.identifier.endpage408
dc.identifier.issue3
dc.identifier.startpage403
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2024.1099972
dc.identifier.urihttps://hdl.handle.net/11454/116455
dc.identifier.volume54
dc.identifier.wosWOS:001406485200016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorFafal, Tugce
dc.institutionauthorKayalar, Husniye
dc.institutionauthorBirim, Dervis
dc.institutionauthorArmagan, Guliz
dc.institutionauthorTuzun, Burcu Sumer
dc.institutionauthorKivcak, Bijen
dc.institutionauthorid0000-0002-7445-5855
dc.institutionauthorid0000-0001-7882-0517
dc.institutionauthorid0000-0002-5094-9949
dc.institutionauthorid0000-0001-6466-2263
dc.institutionauthorid0000-0002-9194-3447
dc.institutionauthorid0000-0001-7645-1930
dc.language.isoen
dc.publisherIstanbul Universitesi
dc.relation.ispartofIstanbul Journal of Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant activity
dc.subjectLamiaceae
dc.subjectNeuroprotective
dc.subjectOxidative stress
dc.titleAssessment of antioxidant and neuroprotective activity of plants from the Lamiaceae family
dc.typeArticle

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