An oestrogen-derivative labeled with 99mTc and its radiopharmaceutical potential

Basit Öğe Kaydı
dc.contributor.authorEnginar H.
dc.contributor.authorÜnak P.
dc.contributor.authorYurt F.
dc.contributor.authorZümrüt Biber F.
dc.date.accessioned2019-10-27T08:59:59Z
dc.date.available2019-10-27T08:59:59Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractAn oestrogen derivative 3,17-?-oestradiolyl propyl 1,4,8,11-tetraazacyclotetradecanyl-1-(4-methylbenzoic acid)ester (ESTCPTA) that is 3,17-?-oestradiolyl propinol coupled to 1-(4-methylbenzoic acid)1,4,8,11-tetraazacyclotelxadecane (CPTA) was synthesized in five steps. The product was purified by recrystallization in ethyl alcohol, and analysed by NMR and IR spectroscopy. ESTCPTA was labeled with 99mTc and radio thin layer chromatography (RTLC) and radio-paper electrophoresis were used to determine the radiochemical yields. Specific activity was approximately 23.7 GBq/mmol and the labeling yield was over 95%. The biodistribution studies were performed on female Albino Wistar rats. The rats were sacricified by ether narcotization at certain time intervals and the activity of the organs was counted by a gamma counter. The activity per gram tissue was calculated and time activity curves were generated.en_US
dc.description.sponsorshipInternational Atomic Energy Agencyen_US
dc.description.sponsorshipThe authors thanks for the financial supports from Ege University Research Funds, Afyon Kocatepe University Research Fund and International Atomic Energy Agency (IAEA) Scientific Collaboration Project. They are grateful to Schering Alman Ilac ve Ecza Ticaret Ltd. that supplied the ethynyl oestradiol as a gift for chemical synthesis and to also Dr. Cavit KAZAZ from Atatürk University at Erzurum-Turkey for this kind assistance in NMR analyses and Dr. Mahmoud ASLANI for the assistance in statistical analysis. --en_US
dc.identifier.doi10.1023/A:1014898628890
dc.identifier.endpage479en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage473en_US
dc.identifier.urihttps://doi.org/10.1023/A:1014898628890
dc.identifier.urihttps://hdl.handle.net/11454/27956
dc.identifier.volume251en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAn oestrogen-derivative labeled with 99mTc and its radiopharmaceutical potentialen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu