Matrix metalloproteinases and atherosclerosis: Review [Matriks metalloproteinaz enzimleri ve ateroskleroz]
Küçük Resim Yok
Tarih
2006
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkiye Klinikleri
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Matrix metalloproteinases (MMPs) are a family of Zn++- and Ca++-dependent neutral endopeptidases that degrade components of extracellular matrix (ECM). The activity of MMPs is essential for many of the processes involved in atherosclerotic plaque formation, such as infiltration of inflammatory cells, smooth muscle cell migration and proliferation. Furthermore, MMPs have also been implicated in events leading to plaque destabilization and rupture. The activity of MMPs is tightly controlled by endogen tissue inhibitors (Tissue inhibitors of metalloproteinases; TIMPs), under physiological conditions. However, during atherosclerotic plaque development, MMP activity is increased by rising cytokine- and growth factor-stimulating gene transcription, elevated zymogen activation and an imbalance in the MMP/TIMP ratio. It is therefore conceivable that inhibition of MMPs or re-establishing the MMP/TIMP balance may be useful in treating the symptoms of atherosclerosis. Recent studies demonstrated that synthethic MMP inhibitors were likely to be useful in treating the symptoms of atherosclerosis. The objective of this review was to assist the better understanding of the effects and contributions of MMPs on the pathogenesis of atherosclerosis. Understanding of the roles of MMPs in the pathogenesis of atherosclerosis may give rise to the proposition of new approaches for the treatment of life-threatening atherosclerotic disorders and to the development of new specific MMP inhibitors as pharmacological agents. Copyright © 2006 by Türkiye Klinikleri.
Açıklama
Anahtar Kelimeler
Atherosclerosis, Extracellular matrix, Matrix metalloproteinase
Kaynak
Turkiye Klinikleri Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
26
Sayı
5
