Vasorelaxant effects of glibenclamide on rat thoracic aorta

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dc.contributor.authorErtuna E.
dc.contributor.authorYasa M.
dc.date.accessioned2019-10-27T00:10:03Z
dc.date.available2019-10-27T00:10:03Z
dc.date.issued2005
dc.departmentEge Üniversitesien_US
dc.description.abstractThe purpose of this study was to investigate the effect of glibenclamide, a selective ATP-sensitive K+ (KATP) channel blocker, on agonist-induced contractions in isolated rat aortic rings. The possible involvement of endothelium in glibenclamide-induced response was also investigated. The concentration-response curves of prostaglandin F 2?(PGF2?; 0.1 nM-30 µM), serotonin (5-hydroxytryptamine, 5-HT; 1 nM-30 µM) and phenylephrine (1 nM-30 µM) were obtained in the absence or presence of glibenclamide (1, 3 or 10 µM). Maximum agonist-induced contractions in the presence of glibenclamide 1, 3 and 10 µM were decreased by 30±5, 64±3 and 86±2 percent for PGF2? and 41±11, 50±11 and 65±5 percent for 5-HT respectively. Phenylephrine-induced contractions remained unaltered by glibenclamide 10 µM. The inhibitory effect of glibenclamide (10 µM) on PGF2?- or 5-HT-induced contractions were attenuated upon N ?-nitro-L-arginin (L-NNA; 100 µM) plus indomethacin (10 µM) incubation. The inhibitory effect of glibenclamide on PGF 2?-induced contractions was also assessed in endothelium-denuded arteries and the inhibitory effect of glibenclamide was greater in endothelium-denuded arteries than in endothelium-intact arteries pretreated with L-NNA plus indomethacin (64±4% versus 46±10%, respectively). These results suggest that glibenclamide could act through multiple sites in either endothelium or the underlying arterial smooth muscle and thus serve as a non-selective muscle relaxant at high concentration.en_US
dc.identifier.endpage128en_US
dc.identifier.issn1015-3918
dc.identifier.issn1015-3918en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://hdl.handle.net/11454/21859
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndotheliumen_US
dc.subjectGlibenclamideen_US
dc.subjectProstaglandin F2? serotoninen_US
dc.subjectRat aortaen_US
dc.titleVasorelaxant effects of glibenclamide on rat thoracic aortaen_US
dc.typeArticleen_US

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