Optimization of Solid Lipid Nanoparticles using Gene Expression Programming (GEP)

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dc.contributor.authorAksu, Buket
dc.contributor.authorGokce, Evren H.
dc.contributor.authorRencber, Seda
dc.contributor.authorOzyazici, Mine
dc.date.accessioned2019-10-27T22:05:52Z
dc.date.available2019-10-27T22:05:52Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this work was to apply the INForm V5.1 GEP program in the development and optimization of different solid lipid nanoparticles (SLN) formulations using physical parameters to achieve the best combination of materials. SLN have been produced by high-shear homogenization, and the formulations have been characterized for their mean particle size, polydispersity index and zeta potential, and the most promising formulations in terms of physicochemical stability have been identified applying the INForm V5.1 GEP program. The data obtained from the laboratory results, following analysis of the variables allowed us to reach most appropriate formulation among 4 different types of SLN. It has been shown that when artificial intelligence is used in the product development phase, the desired result will be obtained with less experiments in shorter time.en_US
dc.description.sponsorshipResearch Foundation of Ege UniversityEge University [07/ECZ/014]en_US
dc.description.sponsorshipThe authors wish to thank the Research Foundation of Ege University (07/ECZ/014) for financial support given to this study.en_US
dc.identifier.endpage684en_US
dc.identifier.issn0326-2383
dc.identifier.issn0326-2383en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage675en_US
dc.identifier.urihttps://hdl.handle.net/11454/48626
dc.identifier.volume33en_US
dc.identifier.wosWOS:000337944700020en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherColegio Farmaceuticos Provincia De Buenos Airesen_US
dc.relation.ispartofLatin American Journal of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArtifical neural networken_US
dc.subjectGene expression programmeen_US
dc.subjectOptimizationen_US
dc.subjectSolid lipid nanoparticles (SLN)en_US
dc.titleOptimization of Solid Lipid Nanoparticles using Gene Expression Programming (GEP)en_US
dc.typeArticleen_US

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