The effect of serum lipid levels on peripheral blood hematopoietic stem cell levels

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dc.contributor.authorYildirim Simsir I.
dc.contributor.authorDonmez A.
dc.contributor.authorKabaroglu C.
dc.contributor.authorYavasoglu I.
dc.contributor.authorBasol G.
dc.contributor.authorGungor A.
dc.contributor.authorTombuloglu M.
dc.date.accessioned2021-05-03T20:59:01Z
dc.date.available2021-05-03T20:59:01Z
dc.date.issued2021
dc.description.abstractIntroduction: There are limited numbers of available retrospective studies on various hematological diseases treated with stem cell mobilization therapy. In the present study, we aimed to demonstrate the effects of serum lipid levels on peripheral blood CD34+ (PBCD34+) cell counts as well as the changes in serum lipid levels during stem cell mobilization process. Method: PBCD34+ cell counts were compared between hypercholesterolemic patients and healthy individuals. Additionally, total cholesterol (TChol), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), and triglyceride (TG) levels were measured from healthy donors who underwent stem cell mobilization, at different time points (prior to filgrastim [phase 1], prior to apheresis [phase II], and the first week following apheresis [phase III]. Results: In the hypercholesterolemia group, the PBCD34+ cell count was found to be higher among patients with elevated LDL-C (2.6 ± 0.35/?L vs. 1.7 ± 0.17/?L, p = 0.003) and TChol (2.6 ± 0.34/?L vs. 1.7 ± 0.14/?L, p = 0.006) in comparison to the healthy controls. In the mobilization group, phase II HDL-C levels (35.3 ± 2.8 mg/dL) were found to be lower than both phase I (45.6 ± 2.1 mg/dL) and phase III (44.5 ± 2.6 mg/dL) (p = 0.007). Phase II TChol levels (183.5 ± 10.0 mg/dL) were lower than both phase I (216.8 ± 8.5 mg/dL) and phase III (212.2 ± 8.4 mg/dL) (p = 0.02). At phase II, there was an inverse correlation between PBCD34+ cell count and HDL-C (r = - 0.57, p = 0.003). Discussion: Our results indicate that, while increased LDL-C level is the determinant of baseline PBCD34+ cell count, reduced HDL-C is the determinant of PBCD34+ cell count during mobilization process. © 2021 Elsevier Ltden_US
dc.description.sponsorshipEge Üniversitesi: 12-5/3 Türk Hematoloji Derneği: 2013/5en_US
dc.description.sponsorshipThis project was supported by the Turkish Society of Hematology, Turkey (2013/5, Ege University Research Ethics Committee Decision Number: 12-5/3).en_US
dc.identifier.doi10.1016/j.transci.2021.103074
dc.identifier.issn1473-0502
dc.identifier.issn1473-0502en_US
dc.identifier.pmid33574011en_US
dc.identifier.scopus2-s2.0-85100612467en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2021.103074
dc.identifier.urihttps://hdl.handle.net/11454/71542
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCholesterolen_US
dc.subjectHematopoietic stem cellen_US
dc.subjectLipid levelsen_US
dc.subjectMobilizationen_US
dc.titleThe effect of serum lipid levels on peripheral blood hematopoietic stem cell levelsen_US
dc.typeArticleen_US

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