Imatinib treatment alone in philadelphia-positive acute lymphoblastic leukemia: Is it enough?

Basit Öğe Kaydı
dc.contributor.authorAy Y.
dc.contributor.authorYilmaz D.
dc.contributor.authorBalkan C.
dc.contributor.authorKarapinar B.
dc.contributor.authorKaradas N.
dc.contributor.authorKavakli K.
dc.date.accessioned2019-10-26T22:08:55Z
dc.date.available2019-10-26T22:08:55Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractBCR-ABL fusion gene t(9;22)(q34;q11) occurs in only 3% of pediatric acute lymphoblastic leukemia (ALL) cases. Previously, less than 40% of Philadelphia-positive ALL patients were cured with intensive chemotherapy. The use of imatinib (340 mg/m2/day) added to an intensive chemotherapy regimen has improved the outcome in this population at 3 years to an event-free survival of 80%. Imatinib treatment alone was administered after remission induction chemotherapy to a patient with Philadelphia-positive ALL who presented with serious chemotherapy toxicity, so that intensive chemotherapy could not be maintained. This is the only patient in the literature who survived remission for more than 2.5 years with imatinib treatment only. Copyright © 2011 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000330102
dc.identifier.endpage326en_US
dc.identifier.issn1662-6575
dc.identifier.issn1662-6575en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage323en_US
dc.identifier.urihttps://doi.org/10.1159/000330102
dc.identifier.urihttps://hdl.handle.net/11454/19301
dc.identifier.volume4en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofCase Reports in Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectImatiniben_US
dc.subjectPediatricsen_US
dc.subjectPhiladelphia-positive acute lymphoblastic leukemiaen_US
dc.titleImatinib treatment alone in philadelphia-positive acute lymphoblastic leukemia: Is it enough?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu