Detection of miRNA Expression Alteration in Diffuse and High Grade Glial Tumors

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dc.contributor.authorYilmaz Susluer, Sunde
dc.contributor.authorBiray Avci, Cigir
dc.contributor.authorDogan Sigva, Zeynep Ozlem
dc.contributor.authorBalci, Tugce
dc.contributor.authorKayabasi, Cagla
dc.contributor.authorAkalin, Taner
dc.contributor.authorDalbasti, Tayfun
dc.contributor.authorGunduz, Cumhur
dc.date.accessioned2019-10-27T22:30:02Z
dc.date.available2019-10-27T22:30:02Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: It was aimed to determine the expression profiles of miRNAs in patients with diffuse and anaplastic brain tumors. Methods: miRNA expression profiles of 50 cases (19 Female, 31 Male) diagnosed with brain tumor [32 Glioblastoma (GBM), 10 diffuse astrocytoma (DA), 8 anaplastic oligodendroglioma (AO)] in Ege University, Department of Neurosurgery and of brain tumor cell lines (U-87 MG, U-118 MG and LN18) studied by the microarray method. Results: In all cases miR-21 expression level was high and no miR-124 expression was detected. In GBM, miR-495 and miR-432 expression showed significant 2-fold increase, and miR-708-3p, mir-339-5p and miR-4286 expressions 4-fold, mir-331-3p, miR-625-3p, and miR-20a-3p showed 5-fold reduction compared to cell lines. miRNA expressions compared GBM and AO, it was detected that miR-34c-3p, miR-132-5p, mir-605, miR-3130-3p, miR3127, mir-517a-pre, mir-548b-3p, miR-921, miR-769-5p were significantly increased. mir-204 expression was significantly decreased in AO compared to cell lines. In DA, miRNA expression was significantly increased in 18 and decreased in 7. There was no significant miRNA expression changes in AO compared with DA. miRNA expressions of DA, AO and GBM cases were compared and significant alterations were found in 29 miRNA expressions. Conclusion: miRNA expression profiles of GBM were significantly different from AO. It was emphasized that, new genes could be effective in tumor development supposed to be regulated by miRNAs. New specific gene targets regulated by miRNA expression could be predicted good clinical outcome in brain tumors.en_US
dc.identifier.endpage88en_US
dc.identifier.issn1302-1664
dc.identifier.issn1302-1664en_US
dc.identifier.issue1en_US
dc.identifier.startpage64en_US
dc.identifier.urihttps://hdl.handle.net/11454/51196
dc.identifier.volume32en_US
dc.identifier.wosWOS:000351690100010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal of Neurological Sciences-Turkishen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiffuse astrocytomaen_US
dc.subjectoligodendrogliomaen_US
dc.subjectGBMen_US
dc.subjectmiRNAen_US
dc.subjectmicroarrayen_US
dc.titleDetection of miRNA Expression Alteration in Diffuse and High Grade Glial Tumorsen_US
dc.typeArticleen_US

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