Microfabricated Electrochemical Sensor for the Detection of Radiation-Induced DMA Damage
Küçük Resim Yok
Tarih
1997
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
An electrochemical biosensor protocol for the detection of radiation-induced DNA damage is described. The procedure employs a dsDNA-coated screen-printed electrode and relies on changes in the guanine-DNA oxida-tion signal upon exposure to ultraviolet radiation. The decreased signal is ascribed primarily to conformational changes in die DNA and to the photoconversion of the guanine-DNA moiety to a nonelectroactive monomeric base product. Factors influencing the response of these microfabricated DNA sensors, such as irradiation time, wavelength, and distance, are explored, and future prospects are discussed. Similar results are given for the use of bare strip electrodes in connection with irradiated DNA solutions.
Açıklama
Anahtar Kelimeler
Kaynak
Analytical Chemistry
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
69
Sayı
7
