Cellulose acetate-chitosan based electrospun nanofibers for bio-functionalized surface design in biosensing

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dc.contributor.authorYezer, Irem
dc.contributor.authorDemirkol, Dilek Odaci
dc.date.accessioned2020-12-01T11:57:54Z
dc.date.available2020-12-01T11:57:54Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractProduction of multifunctional biomaterials in nanoscale is one of the most popular topics in nanotechnology related to biological applications because of its biocompatibility and biodegradability. Herein, cellulose acetate (CA) was blended with chitosan (CS) for the formation of non-soluble electrospun nanofibers in aqueous medium. Amine-functionalized nanofiber surfaces were obtained using carbohydrates, which is an advantage for biomolecule immobilization by covalent bonds. Different solvent systems and CA-CS feeding ratio were examined to obtain ultrafine non-beaded nanofibers. After showing the surface characteristics of CA-CS nanofibers, glucose oxidase (GOx) was immobilized on CA-CS coated electrode by covalent conjugation. Cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy measurements were carried out to prove the surface modification. Finally, CA-CS/GOx platform was investigated to detect glucose in samples and some potential interfering compounds were tested to find out the performance of CA-CS/GOx. CA-CS electrospun nanofibers were well-characterized and applied successfully to fabricate repeatable electrochemical enzymatic biosensor for the first time in this paper.en_US
dc.description.sponsorshipEge University Scientific Research Projects Coordination UnitEge University [18-FEN-005]; Aliye Uster Foundationen_US
dc.description.sponsorshipThis study is supported by Ege University Scientific Research Projects Coordination Unit (Project Number: 18-FEN-005). Authors acknowledge Aliye Uster Foundation for financial support of this research.en_US
dc.identifier.doi10.1007/s10570-020-03486-y
dc.identifier.issn0969-0239
dc.identifier.issn1572-882X
dc.identifier.issn0969-0239en_US
dc.identifier.issn1572-882Xen_US
dc.identifier.scopus2-s2.0-85092187607en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1007/s10570-020-03486-y
dc.identifier.urihttps://hdl.handle.net/11454/61851
dc.identifier.wosWOS:000575720000003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCelluloseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCellulose acetateen_US
dc.subjectChitosanen_US
dc.subjectElectrospun nanofibersen_US
dc.subjectElectrospinningen_US
dc.subjectBiosensingen_US
dc.titleCellulose acetate-chitosan based electrospun nanofibers for bio-functionalized surface design in biosensingen_US
dc.typeArticleen_US

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