Antibiotic loaded electrospun poly (lactic acid) nanofiber mats for drug delivery system

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dc.authoridYILDIRIM, Yeliz/0000-0002-3014-4510
dc.authoridsuner, salih/0000-0001-6678-1418
dc.authoridOzturk, Ismail/0000-0002-2669-3090
dc.authorscopusid57212252525
dc.authorscopusid57545440000
dc.authorscopusid6602719646
dc.authorscopusid57214882332
dc.authorscopusid25230307000
dc.authorscopusid55823702000
dc.authorwosidYILDIRIM, Yeliz/AAG-5559-2019
dc.authorwosidyildirim, yeliz/AAT-9491-2021
dc.authorwosidOzturk, Ismail/AFT-1359-2022
dc.authorwosidsuner, salih/AAV-1775-2021
dc.contributor.authorSuner, Salih Can
dc.contributor.authorYildirim, Yeliz
dc.contributor.authorYurt, Fatma
dc.contributor.authorOzel, Derya
dc.contributor.authorOral, Ayhan
dc.contributor.authorOzturk, Ismail
dc.date.accessioned2023-01-12T19:55:14Z
dc.date.available2023-01-12T19:55:14Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractActive material-loaded nanofibers becoming more important, because of their applications in many areas such as wound healing, skin engineering, and drug release. This study was conducted to compare the release kinetics of three different antibiotics loaded on nanofibers in Phosphate-buffered saline (PBS) solution and their inhibition properties against bacteria. The three different commercial antibiotics; vancomycin (VAN), ceftriaxone (CFT), and cefpodoxime (CFD) were loaded into Polylactic acid (PLA) nanofibers via electrospinning process with different percentages; 5%, 7.5%, and 10% weight ratios of PLA. The SEM images of PLA/Antibiotic nanofibers and pure PLA nanofiber revealed an increase in diameters with the presence of antibiotics embedded in PLA nanofiber. The TGA analysis showed that the thermal degradation of CFD and VAN-loaded nanofibers were higher than neat PLA, while the thermal stability of CFT loaded nanofibers was the lowest. In the Tan Delta curves, the Tg temperatures of CFD, VAN, CFT loaded nanofibers and pure PLA nanofiber were determined as 54.56 degrees C, 54.57 degrees C, 53.86 degrees C, and 53.55 degrees C, respectively. As can be seen from the results, the variation of the glass transition temperatures supports the DSC data. Drug releasing behaviors of PLA/Antibiotic nanofibers were investigated by Ultraviolet-Visible Spectroscopy at 280, 242 and 230 nm wavelength for VAN, CFT, and CFD antibiotics, respectively. Drug-releasing amounts were gradually increased by increasing the drug loading amounts from 5% to 10%. PLA-VAN, PLA-CFT, and PLA-CFD nanofibers which contain 10% of drugs were delivered about 79%, 75%, and 29% of drugs linearly within nearly 380 h, 500 h, and 360 h, respectively. The formulations including CFT at different concentrations were found to be effective against Staphylococcus aureus and Escherichia coli in a dose-dependent manner. The formulations including CFD and VAN at different concentrations have also inhibited the growth of S. aureus.en_US
dc.identifier.doi10.1016/j.jddst.2022.103263
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.issn1773-2247en_US
dc.identifier.issn2588-8943en_US
dc.identifier.scopus2-s2.0-85127011483en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2022.103263
dc.identifier.urihttps://hdl.handle.net/11454/76639
dc.identifier.volume71en_US
dc.identifier.wosWOS:000792903100005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal Of Drug Delivery Science And Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectrospinningen_US
dc.subjectNanofiberen_US
dc.subjectIn vitro drug deliveryen_US
dc.subjectAntibacterial activityen_US
dc.subjectControlled-Releaseen_US
dc.subjectVancomycinen_US
dc.subjectMembranesen_US
dc.subjectCompatibilityen_US
dc.titleAntibiotic loaded electrospun poly (lactic acid) nanofiber mats for drug delivery systemen_US
dc.typeArticleen_US

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