The effect of oral anticoagulants on the adhesion and the aggregation of the platelets
Küçük Resim Yok
Tarih
1972
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Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The effect of oral anticoagulants on the adhesion and the aggregation of the platelets was studied. 12 normal subjects, 26 patients with atherosclerosis and 4 patients with other kinds of diseases were submitted to this experiment. Phenprocoumon from the coumarine group was administered to 6 normal subjects and to 15 patients, while phenindione from the indandion group was given to the other 6 normal subjects and to 15 patients. Oral anticoagulants were given as a single dose to the normal persons and to one group of patients and they were administered for a period of 3 wk to another group of patients. The adhesion of the platelets (in vivo and in vitro) and their time of aggregation (with ADP and collagen) were measured before the administration of the drug and on the 1st, 2nd and 4th days after it in one group, and after 1, 2, 3 wk for another group of cases. With the treatment of the oral anticoagulants, there was no significant alteration in the adhesion of the platelets either in the normal subjects or in the patients. But on the 3rd day following the intake of oral anticoagulants, a great acceleration of the aggregation time (induced by ADP and collagen) was observed and it was decided to take this fact into consideration in the oral anticoagulant therapy.
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Kaynak
AEGEAN MED.J.
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
1
Sayı
2
