An electrochemical cytosensor based on a PAMAM modified glassy carbon paste electrode

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dc.contributor.authorTepeli, Yudum
dc.contributor.authorDemir, Bilal
dc.contributor.authorTimur, Suna
dc.contributor.authorAnik, Ulku
dc.date.accessioned2019-10-27T22:29:41Z
dc.date.available2019-10-27T22:29:41Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractA novel electrochemical cytosensor was developed based on PAMAM and a folic acid (FA) modified glassy carbon paste electrode (GCPE) where HeLa cells were utilized as model cancer cells. For this purpose, gold nanoparticles (AuNp), cysteamin (Cys), glutaraldehyde (Glu), PAMAM and FA were immobilized onto the GCPE respectively. After the characterization of the GCPE/AuNp/Cys/Glu/PAMAM/FA cytosensor and optimization of the experimental parameters, analytical characteristics were examined. The linear range was found between 10(2) cells per mL and 10(6) cells per mL. The LOD value was calculated as 100 cells per mL with RSD value of 1.55% (for 5.0 x 10(4) HeLa cells per mL (n = 3)). The selectivity of the GCPE/AuNp/Cys/Glu/PAMAM/FA cytosensor was tested by using the folate negative cell line A549. The cytosensor's performance was also compared with similar previous studies. As a result, a selective, sensitive and practical system was developed.en_US
dc.identifier.doi10.1039/c5ra07893h
dc.identifier.endpage53978en_US
dc.identifier.issn2046-2069
dc.identifier.issn2046-2069en_US
dc.identifier.issue66en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage53973en_US
dc.identifier.urihttps://doi.org/10.1039/c5ra07893h
dc.identifier.urihttps://hdl.handle.net/11454/51144
dc.identifier.volume5en_US
dc.identifier.wosWOS:000356801300099en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofRsc Advancesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAn electrochemical cytosensor based on a PAMAM modified glassy carbon paste electrodeen_US
dc.typeArticleen_US

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