An immunoelectrochemical platform for the biosensing of ‘Cocaine use’

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dc.contributor.authorYilmaz Sengel T.
dc.contributor.authorGuler E.
dc.contributor.authorGumus Z.P.
dc.contributor.authorAldemir E.
dc.contributor.authorCoskunol H.
dc.contributor.authorAkbulut H.
dc.contributor.authorGoen Colak D.
dc.contributor.authorCianga I.
dc.contributor.authorYamada S.
dc.contributor.authorTimur S.
dc.contributor.authorEndo T.
dc.contributor.authorYagci Y.
dc.date.accessioned2019-10-27T08:20:20Z
dc.date.available2019-10-27T08:20:20Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractIn the present work, we demonstrate a novel surface design by combination of benzoylecgonine (BE) antibody and poly-L-phenylalanine bearing electroactive macromonomer (EDOT-BTDA-PPhe). This system served as an electro-immunosensor platform for the analysis of cocaine use by detecting both BE and cocaine. To construct the immunosensor, a glassy carbon electrode was covered with EDOT-BTDA-PPhe. Subsequently, BE antibody was immobilized on the polypeptide chains. The surface modifications were confirmed by electrochemical techniques. The immunosensor was used for the electrochemical detection of BE and cocaine as evidence of drug addiction. For both analytes, linearity was obtained between 0.5–25 µM. Finally, the proposed system was successfully employed for the analysis of synthetic biological fluids. © 2017 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.snb.2017.02.087
dc.identifier.endpage318en_US
dc.identifier.issn0925-4005
dc.identifier.issn0925-4005en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage310en_US
dc.identifier.urihttps://doi.org/10.1016/j.snb.2017.02.087
dc.identifier.urihttps://hdl.handle.net/11454/25607
dc.identifier.volume246en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofSensors and Actuators, B: Chemicalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAbused drug detectionen_US
dc.subjectBiochemical screening toolen_US
dc.subjectCocaineen_US
dc.subjectImmunosensoren_US
dc.subjectSurface modificationen_US
dc.titleAn immunoelectrochemical platform for the biosensing of ‘Cocaine use’en_US
dc.typeArticleen_US

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