Bioassay-guided isolation and identification of Aedes aegypti larvicidal and biting deterrent compounds from Veratrum lobelianum

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dc.contributor.authorTabanca, Nurhayat
dc.contributor.authorAli, Zulfiqar
dc.contributor.authorBernier, Ulrich R.
dc.contributor.authorEpsky, Nancy
dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorKhan, Ikhlas A.
dc.contributor.authorAli, Abbas
dc.date.accessioned2019-10-27T10:46:02Z
dc.date.available2019-10-27T10:46:02Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractAn ethanol extract from Veratrum lobelianum Bernh. rhizomes showed larvicidal activity with LC50 values of 11.79 ppm and 89.9 ppm against rand 4 1 b instar larvae, respectively, at 24 h post-treatment. The extract also showed proportion not biting (PNB) value of 0.76 at 100 mu g/cm(2) against females of Ae. aegypti. Systematic bioassay-guided fractionation of V. lobelianum extract resulted in the isolation of five compounds that were identified as ethyl palmitate (1), ethyl linoleate (2), p-sitosterol (3), resveratrol (4) and oxyresveratrol (5) by GC-MS, H-1-NMR, and C-13-NMR techniques, comparison with literature data, and confirmation with authentic compounds. Compound 2 exhibited larvicidal activity with an LC50 value of 24.1 (22.0-26.2) ppm whereas 1 was inactive. B-Sitosterol (3) displayed the highest larvicidal activity with LC50 = 1.7 (1.3-2.3) ppm and LC90 = 5.1 (3.4-13.8) ppm. Compounds 4 and 5 had larvicidal activity with LC50 values of 18.5 (15.3-22.3) and 22.6 (19.0-26.8) ppm, respectively, and had an equivalent PNB values of 0.75 at 25 nmol/cm(2). In addition, 4 and 5 were explored for their human-based repellency against Ae. aegypti, attractiveness against male medflies Ceratitis capitata, and also evaluated against series of human carcinoma cells (A549, HEK293, HeLa, SH-SY5Y); however, no significant activity was found.en_US
dc.identifier.doi10.1515/chem-2018-0030
dc.identifier.endpage332en_US
dc.identifier.issn2391-5420
dc.identifier.issn2391-5420en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage324en_US
dc.identifier.urihttps://doi.org/10.1515/chem-2018-0030
dc.identifier.urihttps://hdl.handle.net/11454/31240
dc.identifier.volume16en_US
dc.identifier.wosWOS:000431899300004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDe Gruyter Poland Sp Zooen_US
dc.relation.ispartofOpen Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectfatty ethyl estersen_US
dc.subjectphytosterolen_US
dc.subjectstilbenoidsen_US
dc.subjectpest controlen_US
dc.subjectnatural productsen_US
dc.titleBioassay-guided isolation and identification of Aedes aegypti larvicidal and biting deterrent compounds from Veratrum lobelianumen_US
dc.typeArticleen_US

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