Does tumor volume affect survival in patients with operated early-stage non-small-cell lung cancer?

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dc.contributor.authorKaya, Seyda Ors
dc.contributor.authorAkcam, Tevfik Ilker
dc.contributor.authorAkcay, Onur
dc.contributor.authorSamancilar, Ozgur
dc.contributor.authorCeylan, Kenan Can
dc.contributor.authorUsluer, Ozan
dc.date.accessioned2019-10-27T11:19:18Z
dc.date.available2019-10-27T11:19:18Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: This study aims to investigate whether tumor volume affects survival in patients with operated early-stage non-small-cell lung cancer. Methods: A retrospective analysis of 156 patients (146 males, 10 females; mean age 62.3 +/- 8.0 years; range 38 to 79 years) with non-small-cell lung cancer who underwent anatomical resection and mediastinal lymph node dissection between September 2009 and June 2013 was performed. The tumor volumes were calculated using histopathological data. The effect of tumor volume on prognosis and survival was investigated. Results: Of the patients, 116 had Stage I disease and 40 patients had Stage II disease. The mean tumor volume was 38.2 +/- 54.6 (range, 356.15 to 0.01) cm(3), and the mean largest diameter was 4.2 +/- 2.0 (range, 10 to 0.3) cm. In the Cox regression analysis, the tumor volume below the cut-off value (29.69 cm(3)) increased survival with an odds ratio (OR) of 2, and this value was statistically significant (p=0.022). The cut-off value per T factor was 4.5 cm and the OR was 1.7; however, no significant correlation with the survival was observed (p=0.058). Conclusion: The present study found a closer correlation between the tumor volume and survival in contrast to the known correlation between the tumor's largest diameter and survival. Based on our study results, it is recommended to calculate and consider the tumor volume along with the tumor diameter in the staging of lung cancer.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2017.13520
dc.identifier.endpage637en_US
dc.identifier.issn1301-5680
dc.identifier.issn1301-5680en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage633en_US
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2017.13520
dc.identifier.urihttps://hdl.handle.net/11454/32736
dc.identifier.volume25en_US
dc.identifier.wosWOS:000418417300018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLung canceren_US
dc.subjectprognosisen_US
dc.subjectstagingen_US
dc.subjecttumor volumeen_US
dc.titleDoes tumor volume affect survival in patients with operated early-stage non-small-cell lung cancer?en_US
dc.typeArticleen_US

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