Development and radiolabeling of lipid nanoparticles with [Tc-99m]Tc-HMPAO: Characterization, stability, cytotoxicity and cell binding studies

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dc.authoridOZGENC, EMRE/0000-0002-7586-8520
dc.authoridÖZDEMİR, DERYA İLEM/0000-0002-1062-498X
dc.authorscopusid57221835140
dc.authorscopusid56661951100
dc.authorscopusid56662137100
dc.authorscopusid57215657288
dc.authorscopusid55748265800
dc.authorwosidOZGENC, EMRE/AGN-7731-2022
dc.authorwosidÖZDEMİR, DERYA İLEM/ABB-6717-2020
dc.contributor.authorAtlihan-Gundogdu, Evren
dc.contributor.authorEkinci, Meliha
dc.contributor.authorOzgenc, Emre
dc.contributor.authorDemir, Emine Selin
dc.contributor.authorIlem-Ozdemir, Derya
dc.date.accessioned2023-01-12T20:12:43Z
dc.date.available2023-01-12T20:12:43Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractIn this study, we aimed to develop new lipid based nanoparticles (LPNs) and radiolabeled LPNs with [Tc-99m]Tc-HMPAO to investigate its cell binding capacity comparatively with [Tc-99m]Tc-HMPAO on different cancer cells. According to obtained results, LPNs with zeta potential of -27.4 +/- 0.95 mV, particle size of 93.5 +/- 1.17 nm, and polydispersity index of 0.35 +/- 0.04 were successfully developed. The optimum radiolabeling efficiency was found to be above 90% at 15-min of incubation time. The cell binding capacity of [Tc-99m]Tc-HMPAO-LPNs was found to be higher than [Tc-99m]Tc-HIYIPAO in cancer cell lines. The results demonstrated that [Tc-99m]Tc-HMPAO-LPNs may be a promising agent for cancer diagnosis alternatively to [Tc-99m]Tc-HMPAO.en_US
dc.description.sponsorshipEge University, Nuclear Medicine Department; Ege University, Faculty of Pharmacy, Department of Biochemistryen_US
dc.description.sponsorshipThe authors would like to acknowledge the support of Ege University, Nuclear Medicine Department to obtain the [99mTc] Tc radionuclide and HMPAO kit. Also, the authors thank Prof. Petek Ballar KrmzBayrak from Ege University, Faculty of Pharmacy, Department of Biochemistry to support cell culture studies.en_US
dc.identifier.doi10.29228/jrp.106
dc.identifier.endpage101en_US
dc.identifier.issn2630-6344
dc.identifier.issn2630-6344en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85126925154en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage88en_US
dc.identifier.urihttps://doi.org/10.29228/jrp.106
dc.identifier.urihttps://hdl.handle.net/11454/78351
dc.identifier.volume26en_US
dc.identifier.wosWOS:000738259100010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal Of Research In Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLipid nanoparticlesen_US
dc.subjectradiopharmaceuticalsen_US
dc.subjectHMPAOen_US
dc.subjectcell bindingen_US
dc.subjectcancer diagnosisen_US
dc.subjectChitosan Nanoparticlesen_US
dc.subjectIn-Vitroen_US
dc.subjectFormulationen_US
dc.subjectCarriersen_US
dc.titleDevelopment and radiolabeling of lipid nanoparticles with [Tc-99m]Tc-HMPAO: Characterization, stability, cytotoxicity and cell binding studiesen_US
dc.title.alternative99mTc]Tc-HMPAO: Characterization, stability, cytotoxicity and cell binding studiesen_US
dc.typeArticleen_US

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